Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease

  • Authors:
    • Takumi Kawaguchi
    • Yumiko Nagao
    • Hisako Matsuoka
    • Tatsuya Ide
    • Michio Sata
  • Corresponding author:
  • View Affiliations

  • Published online on: Tuesday, July 1, 2008
  • Pages: 105-112 DOI: 10.3892/ijmm.22.1.105

Abstract

Increased insulin resistance is a therapeutic target in patients with chronic liver disease. Branched-chain amino acids (BCAA) have been reported to improve insulin resistance in in vivo experiments. Thus, we investigated the effects of BCAA on insulin resistance in patients with chronic liver disease. Twelve patients with chronic liver disease were enrolled. Each patient was given one sachet of a BCAA-enriched supplement after breakfast and another at bedtime. The effects of the BCAA-enriched supplementation on insulin resistance were examined 30, 60 and 90 days after administration by the homeostasis model assessment method for insulin resistance (HOMA-IR) and for β cell function (HOMA-%B). The HOMA-IR and HOMA-%B values were elevated at baseline, however, these parameters showed no significant changes after administration of the BCAA-enriched supplement in the overall patient population. By stratification via gender, patients in the male group showed a significantly greater elevation in the HOMA-IR value compared to the female patients at baseline. After the administration, the HOMA-IR and HOMA-%B values were significantly decreased only in the male group (9.4±4.8 vs. 2.4±0.7, 657±345 vs. 126±36, respectively; P<0.05). We found that there was a gender difference in chronic viral liver disease-related insulin resistance. Moreover, a BCAA-enriched supplement improved insulin resistance and β cell function in male patients with chronic viral liver disease. Thus, a BCAA-enriched supplement may be a useful therapeutic agent for decreasing insulin resistance in male patients with chronic viral liver disease.
Journal Cover

July 2008
Volume 22 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2014 Impact Factor: 2.088
Ranked #22/123 Medicine Research and Experimental
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APA
Kawaguchi, T., Nagao, Y., Matsuoka, H., Ide, T., & Sata, M. (2008). Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease. International Journal of Molecular Medicine, 22, 105-112. http://dx.doi.org/10.3892/ijmm.22.1.105
MLA
Kawaguchi, T., Nagao, Y., Matsuoka, H., Ide, T., Sata, M."Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease". International Journal of Molecular Medicine 22.1 (2008): 105-112.
Chicago
Kawaguchi, T., Nagao, Y., Matsuoka, H., Ide, T., Sata, M."Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease". International Journal of Molecular Medicine 22, no. 1 (2008): 105-112. http://dx.doi.org/10.3892/ijmm.22.1.105