RB1CC1 activates the p16 promoter through the interaction with hSNF5

  • Authors:
    • Yasuko Ochi
    • Tokuhiro Chano
    • Kaichiro Ikebuchi
    • Hirokazu Inoue
    • Takahiro Isono
    • Akihito Arai
    • Hitosuke Tameno
    • Taketoshi Shimada
    • Yasuo Hisa
    • Hidetoshi Okabe
  • View Affiliations

  • Published online on: May 27, 2011     https://doi.org/10.3892/or.2011.1329
  • Pages: 805-812
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Abstract

RB1-inducible coiled-coil 1 (RB1CC1, also known as FIP200) is involved in dephosphorylation and increase of retinoblastoma tumor suppressor protein (RB1), but the RB1CC1 molecular mechanism in the dephosphorylation of RB1 is not fully understood. We determined that RB1CC1 activates the expression of p16 (also called INK4a/CDKN2a) through the activation of its promoter, using chromatin immunoprecipitation (ChIP) and p16 promoter-luciferase reporter assays. In addition, RB1CC1 essentially requires binding with hSNF5 (also known as BAF47/INI1, a chromatin-remodeling factor) to activate the p16 promoter, in order to enhance the RB1 pathway and acts as a tumor suppressor. Evaluation of the RB1CC1 mechanism of action is expected to provide useful information for clinical practice and future therapeutic strategies in human cancers.

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October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ochi Y, Chano T, Ikebuchi K, Inoue H, Isono T, Arai A, Tameno H, Shimada T, Hisa Y, Okabe H, Okabe H, et al: RB1CC1 activates the p16 promoter through the interaction with hSNF5. Oncol Rep 26: 805-812, 2011
APA
Ochi, Y., Chano, T., Ikebuchi, K., Inoue, H., Isono, T., Arai, A. ... Okabe, H. (2011). RB1CC1 activates the p16 promoter through the interaction with hSNF5. Oncology Reports, 26, 805-812. https://doi.org/10.3892/or.2011.1329
MLA
Ochi, Y., Chano, T., Ikebuchi, K., Inoue, H., Isono, T., Arai, A., Tameno, H., Shimada, T., Hisa, Y., Okabe, H."RB1CC1 activates the p16 promoter through the interaction with hSNF5". Oncology Reports 26.4 (2011): 805-812.
Chicago
Ochi, Y., Chano, T., Ikebuchi, K., Inoue, H., Isono, T., Arai, A., Tameno, H., Shimada, T., Hisa, Y., Okabe, H."RB1CC1 activates the p16 promoter through the interaction with hSNF5". Oncology Reports 26, no. 4 (2011): 805-812. https://doi.org/10.3892/or.2011.1329