mRNA overexpression of BAALC: A novel prognostic factor for pediatric acute lymphoblastic leukemia

  • Authors:
    • Zahra Azizi
    • Soheila Rahgozar
    • Alireza Moafi
    • Mohammad Dabaghi
    • Motahareh Nadimi
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  • Published online on: February 26, 2015     https://doi.org/10.3892/br.2015.437
  • Pages: 371-374
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Abstract

BAALC is a novel molecular marker in leukemia that is highly expressed in patients with acute leukemia. Increased expression levels of BAALC are known as poor prognostic factors in adult acute myeloid and lymphoid leukemia. The purpose of the present study was to evaluate the prognostic significance of the BAALC gene expression levels in pediatric acute lymphoblastic leukemia (ALL) and its association with MDR1. Using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), the mRNA expression levels of BAALC and MRD1 were measured in bone marrow samples of 28 new diagnosed childhood ALL patients and 13 children without cancer. Minimal residual disease (MRD) was measured one year after the initiation of the chemotherapy using the RT‑qPCR method. The high level expression of BAALC had a significant association with the pre‑B‑ALL subtype, leukocytosis and positive MRD after one year of treatment in leukemic patients. In addition, a positive correlation between BAALC and MDR1 mRNA expression was shown in this group. In conclusion, to the best of our knowledge, the increase of BAALC expression as a poor prognostic factor for childhood ALL is shown for the first time. Additionally, the correlation between BAALC and MDR1 in mRNA expression levels can aid for an improved understanding of the mechanism through which BAALC may function in ALL and multidrug resistance.
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May-2015
Volume 3 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Azizi Z, Rahgozar S, Moafi A, Dabaghi M and Nadimi M: mRNA overexpression of BAALC: A novel prognostic factor for pediatric acute lymphoblastic leukemia. Biomed Rep 3: 371-374, 2015
APA
Azizi, Z., Rahgozar, S., Moafi, A., Dabaghi, M., & Nadimi, M. (2015). mRNA overexpression of BAALC: A novel prognostic factor for pediatric acute lymphoblastic leukemia. Biomedical Reports, 3, 371-374. https://doi.org/10.3892/br.2015.437
MLA
Azizi, Z., Rahgozar, S., Moafi, A., Dabaghi, M., Nadimi, M."mRNA overexpression of BAALC: A novel prognostic factor for pediatric acute lymphoblastic leukemia". Biomedical Reports 3.3 (2015): 371-374.
Chicago
Azizi, Z., Rahgozar, S., Moafi, A., Dabaghi, M., Nadimi, M."mRNA overexpression of BAALC: A novel prognostic factor for pediatric acute lymphoblastic leukemia". Biomedical Reports 3, no. 3 (2015): 371-374. https://doi.org/10.3892/br.2015.437