Although matrix metalloproteinase‑1 (MMP‑1) has been considered a factor of crucial importance for breast cancer cells invasion and metastasis, the expression of MMP‑1 in different breast cancer and cancer‑adjacent tissues have not been fully examined. In the present study, immunohistochemical staining was used to detect the MMP‑1 expression in non‑specific invasive ductal carcinoma of the breast, cancer‑adjacent normal breast tissue, lymph node metastatic non‑specific invasive ductal carcinoma of the breast and normal lymph node tissue. The results showed that MMP‑1 expression is different in the above tissues. MMP‑1 had a positive expression in normal lymph node tissue and lymph node metastatic non‑specific invasive ductal carcinoma. The MMP‑1 negative expression rate was only 6.1% in non‑specific invasive ductal carcinoma of the breast and 2.9% in cancer‑adjacent normal breast tissue respectively. MMP‑1 expression is higher in non‑specific invasive ductal carcinoma and lymph node metastatic non‑specific invasive ductal carcinoma compared to cancer‑adjacent normal breast tissue and normal lymph node tissue. In conclusion, higher expression of MMP‑1 in breast cancer may play a crucial role in promoting breast cancer metastasis.

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