Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)

  • Authors:
    • Maria Aparecida Nagai
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  • Published online on: January 25, 2016     https://doi.org/10.3892/br.2016.580
  • Pages: 275-281
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Abstract

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) encodes a member of an evolutionarily conserved pleckstrin homology‑related domain protein family. It was first identified as a potential transcription factor required for Fas expression and activation‑induced apoptosis in mouse T cell hybridomas. The exact molecular and biological functions of PHLDA1 remain to be elucidated. However, its expression is induced by a variety of external stimuli and there is evidence that it may function as a transcriptional activator that acts as a mediator of apoptosis, proliferation, differentiation and cell migration dependent on the cellular type and context. Recently, PHLDA1 has received attention due to its association with cancer. In the present review, the current knowledge of PHLDA1 protein structure, expression regulation and function is summarized. In addition, the current data in the literature is reviewed with regards to the role of PHLDA1 in cancer pathogenesis.
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March-2016
Volume 4 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Nagai MA: Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review). Biomed Rep 4: 275-281, 2016
APA
Nagai, M.A. (2016). Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review). Biomedical Reports, 4, 275-281. https://doi.org/10.3892/br.2016.580
MLA
Nagai, M. A."Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)". Biomedical Reports 4.3 (2016): 275-281.
Chicago
Nagai, M. A."Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)". Biomedical Reports 4, no. 3 (2016): 275-281. https://doi.org/10.3892/br.2016.580