Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration

  • Authors:
    • Chul-Hong Park
    • Hyung-U Son
    • Minsik Son
    • Sang-Han Lee
  • View Affiliations

  • Published online on: June 30, 2011     https://doi.org/10.3892/etm.2011.314
  • Pages: 843-848
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Abstract

Acer mono Max. sap (AmMs) is called ‘Gol-Li-Su’ or ‘Go-Lo-Soe’ in Korean, which means ‘water beneficial to the bones’. It is reported that the sap contains several types of minerals and sugars. In particular, the calcium concentration of the sap is 36.5 times higher than that of commercial mineral water. Apart from its anti-osteoporosis effect, no reports have addressed the biological activities of AmMs against degenerative diseases. In the present study, we investigated whether AmMs alleviates gastric ulcer-related symptoms in a stress-induced mouse model. To assess the effect of AmMs on gastric ulcer-like symptoms, we carried out a water immersion restraint (WIRE) test and found that AmMs has potential in alleviating gastric ulcers in a concentration-dependent manner. These results indicate that the nutritional factors of the sap mitigate the gastric ulcer-related symptoms caused by stress-induced gastric lesions in mice. AmMs-treated mice exhibited a significant decrease in the ulcer index as compared to those treated with omeprazole or L-arginine. To examine one potential mechanism underlying this effect, we performed reverse transcription-polymerase chain reaction to ascertain whether molecular markers were associated with the mitigation of the gastric lesions. Epithelial and/or tissue nitric oxide synthase (NOS) was assessed to determine whether or not the genes were down-regulated dose-dependently by the sap. The levels of these enzymes were found to be lower in the tissue samples treated with AmMs compared with the levels in the control samples. These findings collectively suggest that AmMs significantly protects the gastric mucosa against WIRE stress-induced gastric lesions, at least in part, by alleviating inducible NOS and/or neuronal NOS expression.
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September-October 2011
Volume 2 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Park C, Son H, Son M and Lee S: Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration. Exp Ther Med 2: 843-848, 2011
APA
Park, C., Son, H., Son, M., & Lee, S. (2011). Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration. Experimental and Therapeutic Medicine, 2, 843-848. https://doi.org/10.3892/etm.2011.314
MLA
Park, C., Son, H., Son, M., Lee, S."Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration". Experimental and Therapeutic Medicine 2.5 (2011): 843-848.
Chicago
Park, C., Son, H., Son, M., Lee, S."Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration". Experimental and Therapeutic Medicine 2, no. 5 (2011): 843-848. https://doi.org/10.3892/etm.2011.314