Does duration of hysteroscopy increase the risk of disease recurrence in patients with endometrial cancer? A multi-centre trial

  • Authors:
    • Clemens B. Tempfer
    • Georg Froese
    • Bernd Buerkle
    • Stephan Polterauer
    • Christoph Grimm
    • Nicole Concin
    • Gerda Hofstetter
    • Monika Weigert
    • Martin K. Oehler
  • View Affiliations

  • Published online on: June 30, 2011     https://doi.org/10.3892/etm.2011.309
  • Pages: 991-995
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Women with endometrial cancer often undergo hysteroscopy during their diagnostic work-up. Whether or not the duration of hysteroscopy affects the rate of positive peritoneal cells and the duration of recurrence-free survival is unknown. In a retrospective multi-centre study, the records of 552 patients with endometrial cancer were investigated. Duration of hysteroscopy was correlated with clinicopathological parameters and patient survival data. The mean [standard deviation (SD)] duration of hysteroscopy was 18.2 (10.5) min in the study population and 17.9 (10.1) min and 17.9 (10.2) min in patients with positive (n=109) and negative peritoneal cytology (n=443), respectively (p=0.9). There were no statistically significant correlations between duration of hysteroscopy and positive peritoneal cytology (p=0.6; rho=-0.028), FIGO stage (p=0.2; rho=-0.080), lymph node involvement (p=0.2; rho=0.106) and patient age (p=0.5; rho=0.033). Longer duration of hysteroscopy (>15 min) was not associated with positive peritoneal cytology (yes vs. no, p=0.8), advanced tumour stage (FIGO I vs. II, III and IV, p=0.3), lymph node involvement (yes vs. no, p=0.1) and patient age (≤65 vs. >65 years, p=0.4). In a multivariate analysis, FIGO stage [p<0.0001; hazard ratio (HR)=5.1, 95% confidence interval (CI) 2.5-10.2], lymph node involvement (p=0.02; HR=3.2, 95% CI 1.2-8.8) and patient age (p=0.003; HR=2.4, 95% CI 1.3-4.2), but not duration of hysteroscopy (p=0.4; HR=1.2, 95% CI 0.7-2.2), were associated with recurrence-free survival. We conclude that longer duration of hysteroscopy does not increase the risk of positive peritoneal cytology and it is not an adverse prognostic factor for recurrence-free survival in patients with endometrial cancer.
View Figures
View References

Related Articles

Journal Cover

September-October 2011
Volume 2 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tempfer CB, Froese G, Buerkle B, Polterauer S, Grimm C, Concin N, Hofstetter G, Weigert M and Oehler MK: Does duration of hysteroscopy increase the risk of disease recurrence in patients with endometrial cancer? A multi-centre trial. Exp Ther Med 2: 991-995, 2011
APA
Tempfer, C.B., Froese, G., Buerkle, B., Polterauer, S., Grimm, C., Concin, N. ... Oehler, M.K. (2011). Does duration of hysteroscopy increase the risk of disease recurrence in patients with endometrial cancer? A multi-centre trial. Experimental and Therapeutic Medicine, 2, 991-995. https://doi.org/10.3892/etm.2011.309
MLA
Tempfer, C. B., Froese, G., Buerkle, B., Polterauer, S., Grimm, C., Concin, N., Hofstetter, G., Weigert, M., Oehler, M. K."Does duration of hysteroscopy increase the risk of disease recurrence in patients with endometrial cancer? A multi-centre trial". Experimental and Therapeutic Medicine 2.5 (2011): 991-995.
Chicago
Tempfer, C. B., Froese, G., Buerkle, B., Polterauer, S., Grimm, C., Concin, N., Hofstetter, G., Weigert, M., Oehler, M. K."Does duration of hysteroscopy increase the risk of disease recurrence in patients with endometrial cancer? A multi-centre trial". Experimental and Therapeutic Medicine 2, no. 5 (2011): 991-995. https://doi.org/10.3892/etm.2011.309