Correlation between apoptosis and TGF-β1 expression in the mucosal epithelium of rat small intestine in a cold stress state

  • Authors:
    • Yongjun Li
    • Dean Tian
  • View Affiliations

  • Published online on: February 28, 2013     https://doi.org/10.3892/etm.2013.983
  • Pages: 1456-1460
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Abstract

The aim of this study was to investigate the correlation between the expression of transforming growth factor‑β1 (TGF‑β1) in the mucosal tissue of rat small intestine and the apoptosis of epithelial cells in the small intestine in a cold‑restraint stress state. Immunohistochemistry was used to detect the expression of TGF-β1. Terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labeling (TUNEL) and DNA agarose gel electrophoresis were used to detect apoptosis. After 8 and 12 h of cold-restraint stress, the positive expression rate of TGF-β1 in the rat small intestine epithelial tissue was 59.09 and 54.16%, respectively. The apoptotic index (AI) of the rat small intestine epithelial cells was 25.69±8.09 and 19.65±6.61%, respectively. The positive expression rate of TGF-β1 in the epithelial tissue of the rat small intestine was positively correlated with the AI of the epithelial cells (r=0.980, P<0.05). The epithelial cells of the rat small intestine exhibited apoptosis under cold‑restraint stress. TGF-β1 is one of the key factors that induces apoptosis of the epithelial cells of the rat small intestine.
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May 2013
Volume 5 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li Y and Li Y: Correlation between apoptosis and TGF-β1 expression in the mucosal epithelium of rat small intestine in a cold stress state. Exp Ther Med 5: 1456-1460, 2013
APA
Li, Y., & Li, Y. (2013). Correlation between apoptosis and TGF-β1 expression in the mucosal epithelium of rat small intestine in a cold stress state. Experimental and Therapeutic Medicine, 5, 1456-1460. https://doi.org/10.3892/etm.2013.983
MLA
Li, Y., Tian, D."Correlation between apoptosis and TGF-β1 expression in the mucosal epithelium of rat small intestine in a cold stress state". Experimental and Therapeutic Medicine 5.5 (2013): 1456-1460.
Chicago
Li, Y., Tian, D."Correlation between apoptosis and TGF-β1 expression in the mucosal epithelium of rat small intestine in a cold stress state". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1456-1460. https://doi.org/10.3892/etm.2013.983