Mitochondrial impairment induces excitotoxic death in cerebellar granule cells

  • Authors: Antonella Bobba, Anna Atlante, Amalia Azzariti, Giuseppe Sgaramella, Pietro Calissano, Ersilia Marra
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  • Published online on: Tuesday, June 1, 2004
  • Pages: 873-876
  • DOI: 10.3892/ijmm.13.6.873

Abstract

A close relationship links mitochondria to cell death with mitochondrial function-impairment considered a major biochemical event in the process of both apoptosis and necrosis. We have used different inhibitors of oxidative phosphorylation, i.e. mitochondrial respiratory chain and ATP synthesis inhibitors, and an uncoupler to investigate the mode of cell death caused by these compounds in cerebellar granule cells. This study shows that in cultured cerebellar granule cells either oxidative phosphorylation inhibitors or uncoupler induce an excitotoxic-like reaction which is mediated by activation of NMDA receptors and is likely due to the release of glutamate. Consistently, survival may occur if the toxic action of glutamate is prevented.
Journal Cover

June 2004
Volume 13 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Bobba, A., Atlante, A., Azzariti, A., Sgaramella, G., Calissano, P., & Marra, E. (2004). Mitochondrial impairment induces excitotoxic death in cerebellar granule cells. International Journal of Molecular Medicine, 13(6), 873-876.
MLA
Bobba, Atlante, Azzariti, Sgaramella, Calissano, and Ersilia Marra. "Mitochondrial impairment induces excitotoxic death in cerebellar granule cells." International Journal of Molecular Medicine International Journal of Molecular Medicine 13.6 (2004): 873-876.
Chicago
Bobba, Atlante, Azzariti, Sgaramella, Calissano, and Ersilia Marra. "Mitochondrial impairment induces excitotoxic death in cerebellar granule cells." International Journal of Molecular Medicine International Journal of Molecular Medicine 13 no. 6 (2004): 873-876.