Immune modulatory effects of Prunella vulgaris L.

  • Authors:
    • Xuya Fang
    • Raymond Chuen-Chung Chang
    • Wai-Hung Yuen
    • Sze Yong Zee
  • View Affiliations

  • Published online on: Tuesday, March 1, 2005
  • Pages: 491-496
  • DOI: 10.3892/ijmm.15.3.491

Abstract

Prunella vulgaris L. (Labiatae) is a perennial plant known as ‘self-heal’ in Western herbal medicine. It has a wide array of biological effects exhibiting numerous therapeutic potentials. Its anti-microbial effects including anti-viral and anti-bacterial effects are, presently, receiving increasing attention. While its anti-viral effects are attributed mainly to the inhibition of virus replication, the biological mechanisms of its anti-bacterial effects or actions remain unknown. In view of the fact that polysaccharides isolated from medicinal herbs often function as biological response modifier of body immunity, we hypothesized that the anti-microbial effect of polysaccharides isolated from P. vulgaris is probably also mediated via immune modulation. We have isolated four polysaccharides containing fractions from P. vulgaris, one of the fractions, PV2, could markedly stimulate the production of superoxide and nitrite representing nitric oxide from murine macrophage RAW264.7 and brain macrophage BV2 cells. The amount of nitrite and superoxide produced after PV2 stimulation was as high as that seen in stimulation using bacterial endotoxin lipopolysaccharide (LPS), and this stimulatory response is dose-dependent. In addition to monocyte/macrophage, PV2 also stimulated the proliferation of splenocytes. In this study, we have shown that the polysaccharides isolated from P. vulgaris have marked immune stimulatory effects, which may bring about the anti-microbial effects of P. vulgaris.
Journal Cover

March 2005
Volume 15 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Fang, X., Chang, R., Yuen, W., & Zee, S. (2005). Immune modulatory effects of Prunella vulgaris L.. International Journal of Molecular Medicine, 15(3), 491-496.
MLA
Fang, Chang, Yuen, and Sze Zee. "Immune modulatory effects of Prunella vulgaris L.." International Journal of Molecular Medicine International Journal of Molecular Medicine 15.3 (2005): 491-496.
Chicago
Fang, Chang, Yuen, and Sze Zee. "Immune modulatory effects of Prunella vulgaris L.." International Journal of Molecular Medicine International Journal of Molecular Medicine 15 no. 3 (2005): 491-496.