Expression of neuropeptides B and W and their receptors in endocrine glands of the rat

  • Authors:
    • Anna Hochol
    • Anna S. Belloni
    • Marcin Rucinski
    • Agnieszka Ziolkowska
    • Rosa Di Liddo
    • Gastone G. Nussdorfer
    • Ludwik K. Malendowicz
  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/ijmm.18.6.1101
  • Pages: 1101-1106
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Abstract

Neuropeptides B and W (NPB and NPW) have been identified as endogenous ligands of the G protein-coupled receptors (GPR) 7 and 8, which in humans are expressed in the hypothalamus and probably involved in the regulation of energy homeostasis and feeding behavior. GPR8 is absent in the rat, where the GPR8-like receptor (GPR8-LR) has been described. Reverse transcription-polymerase chain reaction detected the expression of NPB, NPW, GPR7 and GPR8-LR mRNAs in the hypothalamus, anterior pituitary, thyroid and parathyroid glands, pancreatic islets, adrenal glands, ovary and testis of the rat. Immunocytochemistry demonstrated the presence of NPB and NPW immunoreactivities in these same glands. Radioimmune assay showed that the bolus intraperitoneal injection of 2 nmol/100 g NPB or NPW raised the plasma levels of parathyroid hormone, corticosterone and testosterone. NPB also increased the blood concentration of thyroxine, and NPW that of ACTH and estradiol. Taken together, these findings allow us to suggest that NPB and NPW play a role in the autocrine-paracrine functional regulation of the endocrine system in the rat.

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December 2006
Volume 18 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hochol A, Belloni AS, Rucinski M, Ziolkowska A, Di Liddo R, Nussdorfer GG and Malendowicz LK: Expression of neuropeptides B and W and their receptors in endocrine glands of the rat. Int J Mol Med 18: 1101-1106, 2006
APA
Hochol, A., Belloni, A.S., Rucinski, M., Ziolkowska, A., Di Liddo, R., Nussdorfer, G.G., & Malendowicz, L.K. (2006). Expression of neuropeptides B and W and their receptors in endocrine glands of the rat. International Journal of Molecular Medicine, 18, 1101-1106. https://doi.org/10.3892/ijmm.18.6.1101
MLA
Hochol, A., Belloni, A. S., Rucinski, M., Ziolkowska, A., Di Liddo, R., Nussdorfer, G. G., Malendowicz, L. K."Expression of neuropeptides B and W and their receptors in endocrine glands of the rat". International Journal of Molecular Medicine 18.6 (2006): 1101-1106.
Chicago
Hochol, A., Belloni, A. S., Rucinski, M., Ziolkowska, A., Di Liddo, R., Nussdorfer, G. G., Malendowicz, L. K."Expression of neuropeptides B and W and their receptors in endocrine glands of the rat". International Journal of Molecular Medicine 18, no. 6 (2006): 1101-1106. https://doi.org/10.3892/ijmm.18.6.1101