Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations

  • Authors: Louiza Belkacemi, Ghalem Selselet-Attou, Nurdan Bulur, Karim Louchami, Abdullah Sener, Willy J. Malaisse
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  • Published online on: Wednesday, November 10, 2010
  • Pages: 95-102
  • DOI: 10.3892/ijmm.2010.556

Abstract

The present report concerns several post-mortem variables examined in sand rats that were either maintained on a vegetal diet (control animals) or exposed first during a 20-day transition period to a mixed diet consisting of a fixed amount of a hypercaloric food and decreasing amounts of the vegetal food and then to a 30-day experimental period of exposure to the hypercaloric food. During the latter period, all animals were either given free access to food or fasting daily for 15 h, i.e. from 5.00 p.m. to 8.00 a.m. The body weight, liver wet weight, pancreas wet weight, plasma glucose and haemoglobin A1c concentration, plasma insulin concentration, insulinogenic index, insulin resistance HOMA, plasma cholesterol and triglyceride concentration, liver triglyceride and phospholipid content were all measured. Pancreatic islet (insulin, GLUT2) and liver (lipid droplets) histology were also examined. The main findings consisted in a lower body weight of fasting than non-fasting animals, a higher liver weight in non-diabetic and diabetic rats than in control non-fasting (but not so in fasting) animals, a decrease of pancreas weight in non-diabetic and diabetic as distinct from control animals, a fasting-induced decrease in plasma glucose, plasma insulin and insulin resistance HOMA, plasma cholesterol and triglyceride concentration and triglyceride liver content.
Journal Cover

January 2011
Volume 27 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
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APA
Belkacemi, L., Selselet-Attou, G., Bulur, N., Louchami, K., Sener, A., & Malaisse, W. (2011). Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations. International Journal of Molecular Medicine, 27(1), 95-102.
MLA
Belkacemi, Selselet-Attou, Bulur, Louchami, Sener, and Willy Malaisse. "Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations." International Journal of Molecular Medicine International Journal of Molecular Medicine 27.1 (2011): 95-102.
Chicago
Belkacemi, Selselet-Attou, Bulur, Louchami, Sener, and Willy Malaisse. "Intermittent fasting modulation of the diabetic syndrome in sand rats. III. Post-mortem investigations." International Journal of Molecular Medicine International Journal of Molecular Medicine 27 no. 1 (2011): 95-102.