Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics

  • Authors:
    • Kiyohisa Hiramine
    • Naoyuki Sata
    • Akio Ido
    • Ryozo Kamimura
    • Kentaro Setoyama
    • Kou Arai
    • Norihito Nuruki
    • Yasuhiro Tanaka
    • Hirofumi Uto
    • Hirohito Tsubouchi
  • View Affiliations

  • Published online on: February 10, 2011     https://doi.org/10.3892/ijmm.2011.616
  • Pages: 497-502
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Abstract

Hepatocyte growth factor (HGF) is a multifunctional growth factor with mitogenic, anti-apoptotic and anti-fibrotic activities. In this study, we investigated the effect of administration of recombinant human HGF on pulmonary arterial hypertension. Pulmonary arterial hypertension was induced in rats by a single injection of monocrotaline (MCT) and recombinant human HGF (0.12 mg/day) was administered into the right ventricle cavity using osmotic pumps, which were implanted subcutaneously 21 days after MCT injection. Continuous intravenous delivery of recombinant human HGF for 14 days led to prolonged survival of animals suffering from severe MCT-induced pulmonary arterial hypertension. Although a bolus injection of recombinant human HGF did not affect pulmonary arterial pressure, a 14-day administration of recombinant human HGF attenuated the inflammatory cell infiltrate, matrix accumulation and vascular medial thickening. As a consequence, the pulmonary lumen was enlarged and the pulmonary arterial pressure was significantly reduced. Additionally, continuous administration of recombinant human HGF suppressed lung tissue expression of platelet-derived growth factor, which plays an important role in the development of pulmonary arterial hypertension. These results indicate that recombinant human HGF possibly has a great potential for improving symptoms and altering the clinical course of pulmonary arterial hypertension.

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April 2011
Volume 27 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hiramine K, Sata N, Ido A, Kamimura R, Setoyama K, Arai K, Nuruki N, Tanaka Y, Uto H, Tsubouchi H, Tsubouchi H, et al: Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics. Int J Mol Med 27: 497-502, 2011
APA
Hiramine, K., Sata, N., Ido, A., Kamimura, R., Setoyama, K., Arai, K. ... Tsubouchi, H. (2011). Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics. International Journal of Molecular Medicine, 27, 497-502. https://doi.org/10.3892/ijmm.2011.616
MLA
Hiramine, K., Sata, N., Ido, A., Kamimura, R., Setoyama, K., Arai, K., Nuruki, N., Tanaka, Y., Uto, H., Tsubouchi, H."Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics". International Journal of Molecular Medicine 27.4 (2011): 497-502.
Chicago
Hiramine, K., Sata, N., Ido, A., Kamimura, R., Setoyama, K., Arai, K., Nuruki, N., Tanaka, Y., Uto, H., Tsubouchi, H."Hepatocyte growth factor improves the survival of rats with pulmonary arterial hypertension via the amelioration of pulmonary hemodynamics". International Journal of Molecular Medicine 27, no. 4 (2011): 497-502. https://doi.org/10.3892/ijmm.2011.616