Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers

  • Authors:
    • Evangelia Skarmoutsou
    • Fabio D'Amico
    • Maurizio Marchini
    • Franca Stivala
    • Grazia Malaponte
    • Raffaella Scorza
    • Maria Clorinda Mazzarino
  • View Affiliations

  • Published online on: March 31, 2011     https://doi.org/10.3892/ijmm.2011.661
  • Pages: 873-877
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Abstract

The objective of this study was to determine whether the matrix metalloproteinase-9 (MMP-9) rs3918242 single nucleotide polymorphism may confer susceptibility to systemic sclerosis (SSc) with and without ulcers in an Italian Caucasian population. The MMP-9 rs3918242 functional polymorphism was genotyped in 461 subjects of Italian Caucasian origin: 228 patients with SSc (92 with and 136 without ulcers) and 233 unrelated healthy individuals. The SNP under study was in Hardy-Weinberg equilibrium in the control population. Genotype and allele distributions between SSc patients, with or without ulcers, were not statistically significant (p>0.05). A significant increase of the genotype C/T was observed in male SSc patients without ulcers when compared to patients with ulcers (P=0.04). The MMP-9 rs3918242 functional polymorphism is not associated with susceptibility to SSc. However, the presence of the polymorphism may have a protective effect on the development of ulcers in SSc male patients.

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June 2011
Volume 27 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Skarmoutsou E, D'Amico F, Marchini M, Stivala F, Malaponte G, Scorza R and Mazzarino MC: Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers. Int J Mol Med 27: 873-877, 2011
APA
Skarmoutsou, E., D'Amico, F., Marchini, M., Stivala, F., Malaponte, G., Scorza, R., & Mazzarino, M.C. (2011). Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers. International Journal of Molecular Medicine, 27, 873-877. https://doi.org/10.3892/ijmm.2011.661
MLA
Skarmoutsou, E., D'Amico, F., Marchini, M., Stivala, F., Malaponte, G., Scorza, R., Mazzarino, M. C."Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers". International Journal of Molecular Medicine 27.6 (2011): 873-877.
Chicago
Skarmoutsou, E., D'Amico, F., Marchini, M., Stivala, F., Malaponte, G., Scorza, R., Mazzarino, M. C."Analysis of matrix metalloproteinase-9 gene polymorphism -1562 C/T in patients suffering from systemic sclerosis with and without ulcers". International Journal of Molecular Medicine 27, no. 6 (2011): 873-877. https://doi.org/10.3892/ijmm.2011.661