Open Access

Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation

  • Authors:
    • Min Lin
    • Lin Zhao
    • Wenlong Zhao
    • Jing Weng
  • View Affiliations

  • Published online on: October 9, 2014     https://doi.org/10.3892/ijmm.2014.1960
  • Pages: 1458-1466
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Carotid atherosclerosis is a chronic inflammatory disease of the arterial wall. The present study aimed to identify changes in the gene expression and regulatory factors for atherosclerotic plaques of carotid atherosclerosis from an early to an advanced stage. The original data were downloaded from the NCBI GEO database under accession no. GSE28829. Differentially expressed genes (DEGs) were detected by the Robust Multiarray Average (RMA). The enriched Gene Ontology (GO) terms and pathways for DEGs using DAVID were subsequently identified. The transcriptional and microRNA (miRNA) regulatory network were constructed for the DEGs. Cis-regulatory signals were also investigated. More genes were activated in the advanced stage compared with the early stage. IGHG1 and SPP1 were upregulated, while MYBL1 and PLD were downregulated. The upregulated genes in the advanced stage were involved in atherosclerosis‑related GO terms such as immune, vascular and cell movement homeostasis. The DEGs were significantly enriched in cell adhesion molecules (CAMs) and the focal adhesion pathway. MMP9 and CFL2 played key roles in the transcriptional regulatory network. Moreover, miR-328 was identified as one of the hubs in the miRNA regulatory network. The results may therefore be used to determine the mechanism involved in carotid atherosclerosis.
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December-2014
Volume 34 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lin M, Zhao L, Zhao W and Weng J: Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation. Int J Mol Med 34: 1458-1466, 2014
APA
Lin, M., Zhao, L., Zhao, W., & Weng, J. (2014). Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation. International Journal of Molecular Medicine, 34, 1458-1466. https://doi.org/10.3892/ijmm.2014.1960
MLA
Lin, M., Zhao, L., Zhao, W., Weng, J."Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation". International Journal of Molecular Medicine 34.6 (2014): 1458-1466.
Chicago
Lin, M., Zhao, L., Zhao, W., Weng, J."Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation". International Journal of Molecular Medicine 34, no. 6 (2014): 1458-1466. https://doi.org/10.3892/ijmm.2014.1960