Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer

Retraction in: /10.3892/ijmm.2016.2693

  • Authors:
    • Baisong Lou
    • Xin Zhou
  • View Affiliations

  • Published online on: March 18, 2015     https://doi.org/10.3892/ijmm.2015.2147
  • Pages: 1369-1373
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Abstract

MicroRNAs (miRNAs) can function as tumor suppressors and may provide an efficient strategy for the eradication of cancer. Specific miRNAs can be reintroduced into tumor cells to complement loss of tumor suppression activities. The aim of the present study was to develop miRNA delivery formulation using synthesized miR-451. miR-451 was detected using RT-PCR and tissues were analyzed using immunohistochemical analysis. miRNA delivery formulation proved to be effective either locally or systemically. miR-451 accumulation became evident in tumor cells and exerted an anti-proliferative function. The intravenous delivery of formulated miR-451 did not induce any deregulation in the cytokine levels and liver enzymes. Taken together, the results provide insight into the concept of the systemic delivery of synthetic mimics for tumor suppressor miR-451 and provide potential implications for miRNA therapy in clinical practice.
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May-2015
Volume 35 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Lou B and Lou B: Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693. Int J Mol Med 35: 1369-1373, 2015
APA
Lou, B., & Lou, B. (2015). Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693. International Journal of Molecular Medicine, 35, 1369-1373. https://doi.org/10.3892/ijmm.2015.2147
MLA
Lou, B., Zhou, X."Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693". International Journal of Molecular Medicine 35.5 (2015): 1369-1373.
Chicago
Lou, B., Zhou, X."Systemic delivery of synthetic microRNA-451 is an effective therapeutic strategy for the treatment of lung cancer Retraction in /10.3892/ijmm.2016.2693". International Journal of Molecular Medicine 35, no. 5 (2015): 1369-1373. https://doi.org/10.3892/ijmm.2015.2147