Cefepime, a fourth-generation cephalosporin, in complex with manganese, inhibits proteasome activity and induces the apoptosis of human breast cancer cells

  • Authors:
    • Zhen Zhang
    • Caifeng Bi
    • Yuhua Fan
    • Huannan Wang
    • Yan Bao
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  • Published online on: July 30, 2015     https://doi.org/10.3892/ijmm.2015.2297
  • Pages: 1143-1150
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Abstract

Cefepime (FEP), which is a member of the fourth-generation cephalosporin class, has been extensively studied as a biochemical and antimicrobial reagent in recent years. Manganese (Mn) is important in the biochemical and physiological processes of many living organisms, and it is also high expressed in some tumor tissues. In the present study, we aimed to investigate the proteasome-inhibitory and anti-proliferative properties of 8 metal complexes (FEP‑Cu, FEP-Zn, FEP-Co, FEP-Ni, FEP-Cd, FEP-Cr, FEP-Fe, FEP-Mn) in MDA-MB‑231 human breast cancer cells. The FEP-Mn complex was found to be more potent in its ability to inhibit cell proliferation and proteasome activity than the other compounds tested. Moreover, the FEP-Mn complex inhibited proteasomal chymotrypsin-like (CT-like) activity and induced the apoptosis of breast cancer cells in a dose-and time-dependent manner. Furthermore, the MCF-10A cells were much less sensitive to the FEP complexes compared with the MDA-MB-231 breast cancer cells. These results demonstrated that the FEP-Mn(II) complex has the potential to act as a proteasome inhibitor and apoptosis inducer and therefore has possible future applications in cancer chemotherapy.
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October-2015
Volume 36 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhang Z, Bi C, Fan Y, Wang H and Bao Y: Cefepime, a fourth-generation cephalosporin, in complex with manganese, inhibits proteasome activity and induces the apoptosis of human breast cancer cells. Int J Mol Med 36: 1143-1150, 2015
APA
Zhang, Z., Bi, C., Fan, Y., Wang, H., & Bao, Y. (2015). Cefepime, a fourth-generation cephalosporin, in complex with manganese, inhibits proteasome activity and induces the apoptosis of human breast cancer cells. International Journal of Molecular Medicine, 36, 1143-1150. https://doi.org/10.3892/ijmm.2015.2297
MLA
Zhang, Z., Bi, C., Fan, Y., Wang, H., Bao, Y."Cefepime, a fourth-generation cephalosporin, in complex with manganese, inhibits proteasome activity and induces the apoptosis of human breast cancer cells". International Journal of Molecular Medicine 36.4 (2015): 1143-1150.
Chicago
Zhang, Z., Bi, C., Fan, Y., Wang, H., Bao, Y."Cefepime, a fourth-generation cephalosporin, in complex with manganese, inhibits proteasome activity and induces the apoptosis of human breast cancer cells". International Journal of Molecular Medicine 36, no. 4 (2015): 1143-1150. https://doi.org/10.3892/ijmm.2015.2297