Role of alanyl aminopeptidase in growth and function of human T cells (review).

  • Authors: U Lendeckel, M Arndt, K Frank, T Wex, S Ansorge
  • View Affiliations

  • Published online on: Thursday, July 1, 1999
  • Pages: 17-44
  • DOI: 10.3892/ijmm.4.1.17

Abstract

Alanyl aminopeptidase (APN, CD13) is highly expressed in human monocytes, and anti-CD13 monoclonal antibodies are well established routine markers in leukaemia typing. Due to activation or malignant transformation other leukocyte subpopulations including human T cells exhibit significant APN-gene and surface expression. The function of leukocyte APN is poorly understood, especially the knowledge of physiological ligands/substrates of the enzyme is limited. Abnormal expression of APN on malignant lymphocytes, the activation-dependent induction of APN expression in peripheral T cells and the strong anti-proliferative effects of aminopeptidase inhibitors lead to the interesting hypothesis of a linkage of APN expression and/or function to leukocyte growth. In support of this hypothesis we detected mutations in the APN-gene of patients suffering from leukaemia or lymphoma. This review outlines evidence for APN contributing to the regulation and realisation of lymphocyte growth and function by modulating the mRNA expression of IL-2, IL-1 receptor antagonist, and TGF-beta1 and increasing the activity of MAP kinase p42/Erk2.
Journal Cover

July 1999
Volume 4 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

2012 Impact Factor: 1.957
Ranked #26/121 Medicine Research and Experimental
(total number of cites)

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APA
Lendeckel, U., Arndt, M., Frank, K., Wex, T., & Ansorge, S. (1999). Role of alanyl aminopeptidase in growth and function of human T cells (review).. International Journal of Molecular Medicine, 4(1), 17-44.
MLA
Lendeckel, Arndt, Frank, Wex, and S Ansorge. "Role of alanyl aminopeptidase in growth and function of human T cells (review).." International Journal of Molecular Medicine International Journal of Molecular Medicine 4.1 (1999): 17-44.
Chicago
Lendeckel, Arndt, Frank, Wex, and S Ansorge. "Role of alanyl aminopeptidase in growth and function of human T cells (review).." International Journal of Molecular Medicine International Journal of Molecular Medicine 4 no. 1 (1999): 17-44.