|nPKCdelta a new therapeutic marker for melanoma metastasis? (Review).|
Authors: C A La Porta
Affiliations: Department of General Physiology and Biochemistry, Section of General Pathology, University of Milan, I-20133 Milan, Italy.
Melanoma metastasis is almost uniformly fatal. The identification of signal transduction as crucial effectors for tumorigenesis suggests modalities of gene therapy as well as design of specific drugs. the possible use of nPKCdelta as a therapeutic target is reviewed and discussed. Motivated by recent results, we propose a model in which nPKCdelta modulates melanin synthesis as well as metastasis.