Regulation of apolipoprotein E production in macrophages (review).

  • Authors: L Larkin, L M Khachigian, W Jessup
  • View Affiliations

  • Published online on: Friday, September 1, 2000
  • Pages: 253-261
  • DOI: 10.3892/ijmm.6.3.253

Abstract

Apolipoprotein E (apo E), a 34 kDa component of lipoproteins produced by the liver and in circulating macrophages, plays a critical role in the reverse transport of cholesterol to the liver via the circulation. Cholesterol-rich macrophages (macrophage foam cells) are a major cell type in human atherosclerotic lesions. Apo E deficiency in mice leads to the formation of atherosclerotic lesions. Conversely, macrophage-specific expression of apo E in these deficient mice can reduce the extent of atherosclerosis. These observations, together with the anti-inflammatory and anti-proliferative properties of Apo E, demonstrate an atheroprotective role for the apolipoprotein. Agents that regulate macrophage metabolism are also able to modulate apo E expression. Sterol loading, for example, enhances apo E synthesis and secretion. Additionally, exposure of macrophage foam cells to cholesterol acceptors such as apo A-1, the protein component of high density lipoprotein, further enhance apo E secretion. Cytokines can have a negative regulatory effect on apo E production in macrophages. Apo E expression is controlled at the transcriptional, post-transcriptional and post-translational level. Here, we review the cellular and molecular mechanisms modulating apo E synthesis and secretion in macrophages.
Journal Cover

September 2000
Volume 6 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

2013 Impact Factor: 1.88
Ranked #27/122 Medicine Research and Experimental
(total number of cites)

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APA
Larkin, L., Khachigian, L., & Jessup, W. (2000). Regulation of apolipoprotein E production in macrophages (review).. International Journal of Molecular Medicine, 6(3), 253-261.
MLA
Larkin, Khachigian, and W Jessup. "Regulation of apolipoprotein E production in macrophages (review).." International Journal of Molecular Medicine International Journal of Molecular Medicine 6.3 (2000): 253-261.
Chicago
Larkin, Khachigian, and W Jessup. "Regulation of apolipoprotein E production in macrophages (review).." International Journal of Molecular Medicine International Journal of Molecular Medicine 6 no. 3 (2000): 253-261.