Angiogenesis in adipose tissues and skeletal muscles with rebound weight-gain after diet-restriction in rabbits

  • Authors:
    • M. Morimura
    • O. Ishiko
    • T. Sumi
    • H. Yoshida
    • S. Ogita
  • View Affiliations

  • Published online on: November 1, 2001     https://doi.org/10.3892/ijmm.8.5.499
  • Pages: 499-503
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Abstract

The mechanisms of excessive body weight gain after diet-restriction are still unclear. In this study, we investigated expression of angiogenic factors in adipose tissue and skeletal muscle of rabbits which had rebound weight gains; trying to make inquires into the mechanisms of this rebound weight gain. Ten rabbits were divided into two groups. One group had free food intake (group C), and the other group had restricted food intake until day 40 of the experiments and then had free food intake (group DR). Specimens of adipose tissue and skeletal muscle were collected from each rabbit on days 20, 40, and 60 after the initial examination, and expressions of CD34, vascular endothelial growth factor (VEGF), and platelet-derived endothelial cell growth factor (PD-ECGF) were investigated. Expression of VEGF was significantly strong in the adipose tissue of group DR at the recovery period of body weight. In conclusion, rebound weight gain after a restricted-diet may be associated with angiogenesis in adipose tissue, and the angiogenesis may be induced by VEGF.

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November 2001
Volume 8 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Morimura M, Ishiko O, Sumi T, Yoshida H and Ogita S: Angiogenesis in adipose tissues and skeletal muscles with rebound weight-gain after diet-restriction in rabbits. Int J Mol Med 8: 499-503, 2001
APA
Morimura, M., Ishiko, O., Sumi, T., Yoshida, H., & Ogita, S. (2001). Angiogenesis in adipose tissues and skeletal muscles with rebound weight-gain after diet-restriction in rabbits. International Journal of Molecular Medicine, 8, 499-503. https://doi.org/10.3892/ijmm.8.5.499
MLA
Morimura, M., Ishiko, O., Sumi, T., Yoshida, H., Ogita, S."Angiogenesis in adipose tissues and skeletal muscles with rebound weight-gain after diet-restriction in rabbits". International Journal of Molecular Medicine 8.5 (2001): 499-503.
Chicago
Morimura, M., Ishiko, O., Sumi, T., Yoshida, H., Ogita, S."Angiogenesis in adipose tissues and skeletal muscles with rebound weight-gain after diet-restriction in rabbits". International Journal of Molecular Medicine 8, no. 5 (2001): 499-503. https://doi.org/10.3892/ijmm.8.5.499