Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.

  • Authors: H Nagayasu, J Hamada, D Nakata, T Shibata, M Kobayashi, M Hosokawa, N Takeichi
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  • Published online on: Thursday, January 1, 1998
  • Pages: 197-399
  • DOI: 10.3892/ijo.12.1.197

Abstract

We examined the effects of epidermal growth factor (EGF) on tumor progression of a weakly malignant rat mammary carcinoma cell line, ER-1. In vitro treatment with EGF enhanced tumorigenicity, metastatic capacity and in vitro invasive capacity of ER-1 cells. The increased malignancy of ER-1 cells was reversible, when the cells were pretreated with EGF for 24 h, whereas it was irreversible when pretreated with EGF for 1 month. EGF treatment elevated the intracellular peroxide level in ER-1 cells. When ER-1 cells were treated with EGF in the presence of N-acetylcysteine, a chemical antioxidant, the reversible or irreversible EGF-induced progression was inhibited. These results suggest that the reversible or irreversible tumor progression in ER-1 cells occur in accordance with the duration of exposure to EGF, and that reactive oxygen species may be involved in the progression.
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January 1998
Volume 12 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Nagayasu, H., Hamada, J., Nakata, D., Shibata, T., Kobayashi, M., Hosokawa, M., & Takeichi, N. (1998). Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.. International Journal of Oncology, 12(1), 197-399.
MLA
Nagayasu, Hamada, Nakata, Shibata, Kobayashi, Hosokawa, and N Takeichi. "Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.." International Journal of Oncology International Journal of Oncology 12.1 (1998): 197-399.
Chicago
Nagayasu, Hamada, Nakata, Shibata, Kobayashi, Hosokawa, and N Takeichi. "Reversible and irreversible tumor progression of a weakly malignant rat mammary carcinoma cell line by in vitro exposure to epidermal growth factor.." International Journal of Oncology International Journal of Oncology 12 no. 1 (1998): 197-399.