Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.

  • Authors:
    • Y Fukushima
    • Y Oshika
    • T Tsuchida
    • T Tokunaga
    • H Hatanaka
    • H Kijima
    • H Yamazaki
    • Y Ueyama
    • N Tamaoki
    • M Nakamura
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/ijo.13.5.967
  • Pages: 967-1037
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Abstract

Brain-specific angiogenesis inhibitor (BAI) 1 was recently isolated as a novel p53 inducible gene. BAI1 has been suggested to play a significant role in angiostasis. We studied the expression of BAI1 in 49 colorectal cancer specimens by RT-PCR. BAI1 expression was significantly reduced in colorectal cancers as compared to the extraneoplastic tissues (X(2) test, p=0.041). BAI1 expression was inversely correlated with vascular invasion and metastasis (Fisher's exact test, p 0.045). Moreover, vascularity in the colorectal cancer was inversely correlated with BAI1 gene expression (Mann-Whitney U-test, p=0.0003). These observations suggested that BAI1 expression might inhibit angiogenesis and metastasis of colorectal cancer.

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Nov 1998
Volume 13 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Ueyama Y, Tamaoki N, Nakamura M, Nakamura M, et al: Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.. Int J Oncol 13: 967-1037, 1998
APA
Fukushima, Y., Oshika, Y., Tsuchida, T., Tokunaga, T., Hatanaka, H., Kijima, H. ... Nakamura, M. (1998). Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.. International Journal of Oncology, 13, 967-1037. https://doi.org/10.3892/ijo.13.5.967
MLA
Fukushima, Y., Oshika, Y., Tsuchida, T., Tokunaga, T., Hatanaka, H., Kijima, H., Yamazaki, H., Ueyama, Y., Tamaoki, N., Nakamura, M."Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.". International Journal of Oncology 13.5 (1998): 967-1037.
Chicago
Fukushima, Y., Oshika, Y., Tsuchida, T., Tokunaga, T., Hatanaka, H., Kijima, H., Yamazaki, H., Ueyama, Y., Tamaoki, N., Nakamura, M."Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer.". International Journal of Oncology 13, no. 5 (1998): 967-1037. https://doi.org/10.3892/ijo.13.5.967