Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts

  • Authors:
    • David E. Modrak
    • Marisol D. Rodriguez
    • David M. Goldenberg
    • Walter Lew
    • Rosalyn D. Blumenthal
  • View Affiliations

  • Published online on: February 1, 2002     https://doi.org/10.3892/ijo.20.2.379
  • Pages: 379-384
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Abstract

Evidence suggests that ceramide, generated from a distinct subcellular pool of sphingomyelin (SM) by the action of sphingomyelinases, may be used by cells to propagate apoptotic signals in response to a variety of cytotoxic agents. Since most tumor cells have altered lipid metabolism, it is possible that the intracellular pool of SM used for signaling is decreased. To overcome this, we have attempted to increase the SM content of all intracellular compartments with exogenous SM and examined the impact on 5-fluorouracil (5FU) and irinotecan chemosensitivity. Our data suggest that the efficacy of these two chemotherapeutics for the treatment of HT-29, HCT15 and GW-39 human colonic tumor xenografts can be enhanced by the use of exogenous SM. Furthermore, this enhancement may be due to a reversal of the attenuation of the apoptotic signal found in cancer cells without inducing significant hematopoietic, hepatic or renal toxicity.

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February 2002
Volume 20 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Modrak DE, Rodriguez MD, Goldenberg DM, Lew W and Blumenthal RD: Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts. Int J Oncol 20: 379-384, 2002
APA
Modrak, D.E., Rodriguez, M.D., Goldenberg, D.M., Lew, W., & Blumenthal, R.D. (2002). Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts. International Journal of Oncology, 20, 379-384. https://doi.org/10.3892/ijo.20.2.379
MLA
Modrak, D. E., Rodriguez, M. D., Goldenberg, D. M., Lew, W., Blumenthal, R. D."Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts". International Journal of Oncology 20.2 (2002): 379-384.
Chicago
Modrak, D. E., Rodriguez, M. D., Goldenberg, D. M., Lew, W., Blumenthal, R. D."Sphingomyelin enhances chemotherapy efficacy and increases apoptosis in human colonic tumor xenografts". International Journal of Oncology 20, no. 2 (2002): 379-384. https://doi.org/10.3892/ijo.20.2.379