Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival

  • Authors:
    • Yoshinori Munemoto
    • Yoshiro Iida
    • Jinro Abe
    • Hideo Saito
    • Katsunori Fujisawa
    • Yoshiro Kasahara
    • Tsuyoshi Mitsui
    • Yasuyuki Asada
    • Shouji Miura
  • View Affiliations

  • Published online on: February 1, 2002     https://doi.org/10.3892/ijo.20.2.403
  • Pages: 403-411
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Abstract

We examined the relationship between host as well as tumor factors and postoperative survival rate in patients who received combination therapy of mitomycin C + fluoropyrimidine oral antineoplastics + protein-bound polysaccharide K (PSK) (MFP therapy) after curative resection of colorectal cancer. Markers that determine prognosis, such as preoperative humoral factors (complement 3 and 4), immunosuppressive acidic protein (IAP), lymphocyte transformation (cellular factors) induced by phytohemagglutinin (PHA), pokeweed mitogen (PWM), and PSK, and various tumor markers (CEA, CA19-9) were measured. For each parameter, patients were divided into a high-level and a low-level group according to a predetermined cut-off value, and survival rates were compared between the two groups. The host factors that determined prognosis were 1-month postoperative IAP level [IAP(1M)], preoperative PHA value, and preoperative CA19-9 level. The levels of IAP(1M) <740 μg/ml, preoperative PHA ≥210 (SI value), and preoperative CA19-9 <13 U/ml were associated with a favorable prognosis. When combined with the tumor factors, the prognosis was favorable in Dukes A+B cases with preoperative CA19-9 <13 U/ml, and in Dukes C cases with preoperative PHA ≥210 SI. By the Cox proportional hazard model analysis, among IAP, PHA and CA19-9, CA19-9 was the strongest host factor associated with the prognosis of MFP therapy.

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February 2002
Volume 20 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Munemoto Y, Iida Y, Abe J, Saito H, Fujisawa K, Kasahara Y, Mitsui T, Asada Y and Miura S: Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival. Int J Oncol 20: 403-411, 2002
APA
Munemoto, Y., Iida, Y., Abe, J., Saito, H., Fujisawa, K., Kasahara, Y. ... Miura, S. (2002). Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival. International Journal of Oncology, 20, 403-411. https://doi.org/10.3892/ijo.20.2.403
MLA
Munemoto, Y., Iida, Y., Abe, J., Saito, H., Fujisawa, K., Kasahara, Y., Mitsui, T., Asada, Y., Miura, S."Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival". International Journal of Oncology 20.2 (2002): 403-411.
Chicago
Munemoto, Y., Iida, Y., Abe, J., Saito, H., Fujisawa, K., Kasahara, Y., Mitsui, T., Asada, Y., Miura, S."Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival". International Journal of Oncology 20, no. 2 (2002): 403-411. https://doi.org/10.3892/ijo.20.2.403