The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses

  • Authors:
    • Margit Rosner
    • Angelika Freilinger
    • Gert Lubec
    • Markus Hengstschläger
  • View Affiliations

  • Published online on: November 1, 2005     https://doi.org/10.3892/ijo.27.5.1411
  • Pages: 1411-1424
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Abstract

Tuberous sclerosis (TSC) is an autosomal dominant tumor suppressor gene syndrome affecting about 1 in 6000 individuals. It is characterized by mental retardation and epilepsy. A variety of tumors characteristically occur in different organs of TSC patients. The genes, TSC1 on chromosome 9q34, encoding hamartin, and TSC2 on chromosome 16p13.3, encoding tuberin are responsible for TSC. Hamartin and tuberin form a complex providing a tentative explanation for the similar disease phenotype in TSC patients with mutations in either of these genes. Besides overlap in many features of patients with TSC1 and TSC2 mutations, data accumulated provide evidence for specific clinical differences. Here, we performed microarray analyses of the gene expression response to overexpressed TSC1 or TSC2 in HeLa cells. Out of 2400 analysed genes we found 115 genes to be up-regulated ≥2-fold upon ectopic TSC1 overexpression and 284 genes to be up-regulated ≥2-fold via TSC2. Only 34 of these genes were up-regulated by both, TSC1 and TSC2. Whereas only 7 genes were down-regulated ≥2-fold via TSC1, ectopic TSC2 triggered a ≥2-fold down-regulation of 113 genes. Only 3 of these genes were down-regulated by TSC1 and TSC2. This study provides new insights into the cellular roles of TSC proteins and promotes discussion on whether separable functions of these proteins might be associated with the clinical differences of TSC1- and TSC2-associated disease.

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November 2005
Volume 27 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Rosner M, Freilinger A, Lubec G and Hengstschläger M: The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses. Int J Oncol 27: 1411-1424, 2005
APA
Rosner, M., Freilinger, A., Lubec, G., & Hengstschläger, M. (2005). The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses. International Journal of Oncology, 27, 1411-1424. https://doi.org/10.3892/ijo.27.5.1411
MLA
Rosner, M., Freilinger, A., Lubec, G., Hengstschläger, M."The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses". International Journal of Oncology 27.5 (2005): 1411-1424.
Chicago
Rosner, M., Freilinger, A., Lubec, G., Hengstschläger, M."The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses". International Journal of Oncology 27, no. 5 (2005): 1411-1424. https://doi.org/10.3892/ijo.27.5.1411