The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-κB signal transduction pathways

  • Authors:
    • S. Bar-Yehuda
    • S. M. Stemmer
    • L. Madi
    • D. Castel
    • A. Ochaion
    • S. Cohen
    • F. Barer
    • A. Zabutti
    • G. Perez-Liz
    • L. Del Valle
    • P. Fishman
  • View Affiliations

  • Published online on: Friday, August 1, 2008
  • Pages: 287-295
  • DOI: 10.3892/ijo_00000008

Abstract

The A3 adenosine receptor (A3AR) is highly expressed in tumors and was suggested as a target for cancer treatment. In this study, we show that A3AR is highly expressed in tumor tissues and in peripheral blood mononuclear cells (PBMCs) derived from patients with HCC, as well as from HCC tumor-bearing rats. The high expression level of the receptor was directly correlated to overexpression of NF-κB, known as a transcription factor of A3AR. CF102, a synthetic highly selective agonist to A3AR induced a marked dose response inhibition of tumor growth in N1S1 HCC tumor rats, via de-regulation of the NF-κB and the Wnt signal transduction pathways, resulting in apoptosis of tumor cells. Taken together, A3AR is highly expressed in tumors and PBMCs of HCC patients and tumor-bearing rats. CF102 induced apoptosis and tumor growth inhibition. These data suggest A3AR as a novel targeted therapy to treat HCC.
Journal Cover

August 2008
Volume 33 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Bar-Yehuda, S., Stemmer, S., Madi, L., Castel, D., Ochaion, A., Cohen, S., Barer, F., Zabutti, A., Perez-Liz, G., Del Valle, L., & Fishman, P. (2008). The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-κB signal transduction pathways. International Journal of Oncology, 33(2), 287-295.
MLA
Bar-Yehuda, Stemmer, Madi, Castel, Ochaion, Cohen, Barer, Zabutti, Perez-Liz, Del Valle, and P. Fishman. "The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-κB signal transduction pathways." International Journal of Oncology International Journal of Oncology 33.2 (2008): 287-295.
Chicago
Bar-Yehuda, Stemmer, Madi, Castel, Ochaion, Cohen, Barer, Zabutti, Perez-Liz, Del Valle, and P. Fishman. "The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-κB signal transduction pathways." International Journal of Oncology International Journal of Oncology 33 no. 2 (2008): 287-295.