Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers

  • Authors:
    • Rebecca G. Bagley
    • William Weber
    • Cecile Rouleau
    • Min Yao
    • Nakayuki Honma
    • Shiro Kataoka
    • Isao Ishida
    • Bruce L. Roberts
    • Beverly A. Teicher
  • View Affiliations

  • Published online on: Sunday, March 1, 2009
  • Pages: 619-627
  • DOI: 10.3892/ijo_00000187

Abstract

Tumor development is a complex and dynamic process that involves malignant, vascular, and stromal cells. Endosialin is a tumor endothelial marker (TEM) present in the microvasculature and stroma of human tumors. Cancer-associated fibroblasts (CAF) have been implicated in promoting tumor development and have been associated with mesenchymal stem cells (MSC). Since stem/progenitor cells recruited either from bone marrow or residing in nearby tissues can contribute to pathological processes we investigated endosialin in MSC using a novel monoclonal antibody. Endosialin is highly expressed by CAF and human bone marrow-derived MSC. MSC can form networks in a tube formation assay that is inhibited by an anti-endosialin antibody. Immunohistochemistry for human endosialin in xenograft tumors following co-injection of MSC and cancer cells identified MSC in tumor stroma. MSC are a potential target for anticancer therapeutic intervention and endosialin expression offers a new tool for the identification of MSC. Endosialin expression by both CAF and MSC further implies the potential contribution of MSC to tumor stroma via differentiation into tumor stromal fibroblasts.
Journal Cover

March 2009
Volume 34 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
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APA
Bagley, R., Weber, W., Rouleau, C., Yao, M., Honma, N., Kataoka, S., Ishida, I., Roberts, B., & Teicher, B. (2009). Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers. International Journal of Oncology, 34(3), 619-627.
MLA
Bagley, Weber, Rouleau, Yao, Honma, Kataoka, Ishida, Roberts, and Beverly Teicher. "Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers." International Journal of Oncology International Journal of Oncology 34.3 (2009): 619-627.
Chicago
Bagley, Weber, Rouleau, Yao, Honma, Kataoka, Ishida, Roberts, and Beverly Teicher. "Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers." International Journal of Oncology International Journal of Oncology 34 no. 3 (2009): 619-627.