MicroRNA profiling of human kidney cancer subtypes

  • Authors:
    • David Petillo
    • Eric J. Kort
    • John Anema
    • Kyle A. Furge
    • Ximing J. Yang
    • Bin Tean Teh
  • View Affiliations

  • Published online on: Wednesday, July 1, 2009
  • Pages: 109-114
  • DOI: 10.3892/ijo_00000318

Abstract

Although the functions of most of the identified microRNAs (miRNAs) have yet to be determined, their use as potential biomarkers has been considered in several human diseases and cancers. In order to understand their role in renal tumorigenesis, we screened the expression levels of miRNAs in four subtypes of human renal neoplasms: clear cell, papillary, and chromophobe renal cell carcinomas (RCC) as well as benign renal oncocytomas. We found a unique miRNA signature for each subtype of renal tumor. Furthermore, we identified unique patterns of miRNA expression distinguishing clear cell RCC cases with favorable vs. unfavorable outcome. Specifically, we documented the overexpression of miRs 424 and 203 in clear cell RCC relative to papillary RCC, as well as the inversion of expression of miR-203 in the benign oncocytomas (where it is underexpressed relative to normal kidney) as compared to the malignant chromophobe RCC (where it is overexpressed relative to normal kidney). Our results further suggest that overexpression of S-has-miR-32 is associated with poor outcome. While previous studies have identified unique miRNA expression pattern distinguishing tumors from different anatomical locations, here we extend this principle to demonstrate the utility of miRNA expression profiling to identify a signature unique to various tumor subtypes at a single anatomic locus.
Journal Cover

July 2009
Volume 35 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2013 Impact Factor: 2.773
Ranked #30/202 Oncology
(total number of cites)

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APA
Petillo, D., Kort, E., Anema, J., Furge, K., Yang, X., & Teh, B. (2009). MicroRNA profiling of human kidney cancer subtypes. International Journal of Oncology, 35(1), 109-114.
MLA
Petillo, Kort, Anema, Furge, Yang, and Bin Teh. "MicroRNA profiling of human kidney cancer subtypes." International Journal of Oncology International Journal of Oncology 35.1 (2009): 109-114.
Chicago
Petillo, Kort, Anema, Furge, Yang, and Bin Teh. "MicroRNA profiling of human kidney cancer subtypes." International Journal of Oncology International Journal of Oncology 35 no. 1 (2009): 109-114.