MicroRNA profiling of human kidney cancer subtypes

  • Authors:
    • David Petillo
    • Eric J. Kort
    • John Anema
    • Kyle A. Furge
    • Ximing J. Yang
    • Bin Tean Teh
  • View Affiliations

  • Published online on: July 1, 2009     https://doi.org/10.3892/ijo_00000318
  • Pages: 109-114
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Abstract

Although the functions of most of the identified microRNAs (miRNAs) have yet to be determined, their use as potential biomarkers has been considered in several human diseases and cancers. In order to understand their role in renal tumorigenesis, we screened the expression levels of miRNAs in four subtypes of human renal neoplasms: clear cell, papillary, and chromophobe renal cell carcinomas (RCC) as well as benign renal oncocytomas. We found a unique miRNA signature for each subtype of renal tumor. Furthermore, we identified unique patterns of miRNA expression distinguishing clear cell RCC cases with favorable vs. unfavorable outcome. Specifically, we documented the overexpression of miRs 424 and 203 in clear cell RCC relative to papillary RCC, as well as the inversion of expression of miR-203 in the benign oncocytomas (where it is underexpressed relative to normal kidney) as compared to the malignant chromophobe RCC (where it is overexpressed relative to normal kidney). Our results further suggest that overexpression of S-has-miR-32 is associated with poor outcome. While previous studies have identified unique miRNA expression pattern distinguishing tumors from different anatomical locations, here we extend this principle to demonstrate the utility of miRNA expression profiling to identify a signature unique to various tumor subtypes at a single anatomic locus.

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July 2009
Volume 35 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Petillo D, Kort EJ, Anema J, Furge KA, Yang XJ and Teh BT: MicroRNA profiling of human kidney cancer subtypes. Int J Oncol 35: 109-114, 2009
APA
Petillo, D., Kort, E.J., Anema, J., Furge, K.A., Yang, X.J., & Teh, B.T. (2009). MicroRNA profiling of human kidney cancer subtypes. International Journal of Oncology, 35, 109-114. https://doi.org/10.3892/ijo_00000318
MLA
Petillo, D., Kort, E. J., Anema, J., Furge, K. A., Yang, X. J., Teh, B. T."MicroRNA profiling of human kidney cancer subtypes". International Journal of Oncology 35.1 (2009): 109-114.
Chicago
Petillo, D., Kort, E. J., Anema, J., Furge, K. A., Yang, X. J., Teh, B. T."MicroRNA profiling of human kidney cancer subtypes". International Journal of Oncology 35, no. 1 (2009): 109-114. https://doi.org/10.3892/ijo_00000318