Immunotherapies using autologous whole tumor cell vaccines have great potential in the treatment of cancer. Very few studies report the use of cryotreatment for the preparation of cells in cell-based vaccines. In this study, we demonstrated that a preparation containing cryotreated human breast cancer cells has the same capacity as a preparation containing irradiated human breast cancer cells to induce the activation of immune cells in vivo. The vaccine strategy proposed in this study may provide the experiment basis for the use of autologous or allogeneic breast cancer cells in the cell-based vaccine approach for the treatment of breast cancer and other types of cancer as well.

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