Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review)

  • Authors:
    • Kazuyuki Sato
    • Kenichi Yoshida
  • View Affiliations

  • Published online on: November 1, 2010     https://doi.org/10.3892/ijo_00000758
  • Pages: 1071-1076
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Abstract

Cells are tightly regulated by sophisticated systems. Among such systems, post-translational modification has been intensively studied, and the ubiquitin-proteasome system is one of the best-known proteolytic mechanisms for the timely destruction of regulatory proteins. As progress has been made in research on the ubiquitin-proteasome system, our understanding of fundamental regulatory circuits, such as the cell cycle and circadian rhythms, has progressed. Here, we focused on the SKP1-CUL1-F-box protein of E3 ubiquitin ligase, especially the F-box and additional characteristic domain-containing proteins, as adaptors for regulatory proteins. Accumulating evidence suggests that the F-box and additional characteristic domain-containing proteins are involved in a wide variety of cellular processes and pathogenesis. This raises the possibility that F-box and additional characteristic domain-containing proteins could be used as biomarkers for certain diseases.

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November 2010
Volume 37 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sato K and Sato K: Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review). Int J Oncol 37: 1071-1076, 2010
APA
Sato, K., & Sato, K. (2010). Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review). International Journal of Oncology, 37, 1071-1076. https://doi.org/10.3892/ijo_00000758
MLA
Sato, K., Yoshida, K."Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review)". International Journal of Oncology 37.5 (2010): 1071-1076.
Chicago
Sato, K., Yoshida, K."Augmentation of the ubiquitin-mediated proteolytic system by F-box and additional motif-containing proteins (Review)". International Journal of Oncology 37, no. 5 (2010): 1071-1076. https://doi.org/10.3892/ijo_00000758