IGF gene polymorphisms and breast cancer in African-American and Hispanic women

  • Authors:
    • Marianna Sarkissyan
    • Dhruva Kumar Mishra
    • Yanyuan Wu
    • Xiying Shang
    • Suren Sarkissyan
    • Jaydutt V. Vadgama
  • View Affiliations

  • Published online on: March 30, 2011     https://doi.org/10.3892/ijo.2011.990
  • Pages: 1663-1673
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Abstract

Previous studies from our group and others have shown that increased circulatory levels of the ligand insulin-like growth factor 1 (IGF-1) and decreased levels of the predominant IGF-1 binding protein 3 (IGFBP-3) are associated with an increased incidence of breast cancer and poor outcome. Some studies suggest that, in addition to the influence of environmental factors on the levels of IGF-1 and IGFBP-3, alterations in their gene polymorphisms may play a significant role in the risk of cancer. In this study, we investigated the association between gene polymorphisms along the IGF axis and breast cancer, including the IGF-1 (CA) dinucleotide repeat, IGFBP-3 A-202C single nucleotide polymorphism, and the 2-bp deletion and (AGG)n repeat polymorphisms in the IGF type 1 receptor (IGF-IR). A total of 654 subjects, including both African-American and Hispanic/Latino subjects, were screened for various gene polymorphisms. IGF gene polymorphism genotyping was performed by PCR-GeneScan and PCR-RFLP methods. Our results demonstrated a significant association between the non-19/non-19 IGF-1 (CA)n polymorphism and breast cancer (OR=1.75; 95% CI=1.07-2.88; P=0.027). Furthermore, absence of the wild-type-19 allele and alleles <(CA)19 were strongly associated with breast cancer (OR=1.82; 95% CI=1.20-2.77; P=0.005 and OR=1.70; 95% CI=1.19-2.43; P=0.003, respectively). The association of the non-19/non-19 polymorphism with breast cancer was also more significant in premenopausal women (P=0.04). We did not find any significant association of the IGFBP-3 polymorphism with breast cancer. In the case of IGF-1R polymorphisms, the only significant trend was in the (AGG)5 allele; however, the frequency of this allele was very rare. In summary, our study demonstrated a significant association of IGF-1 polymorphisms and breast cancer. Future studies are necessary to understand the mechanistic value of these polymorphisms in breast cancer risk.

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June 2011
Volume 38 Issue 6

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Spandidos Publications style
Sarkissyan M, Mishra DK, Wu Y, Shang X, Sarkissyan S and Vadgama JV: IGF gene polymorphisms and breast cancer in African-American and Hispanic women. Int J Oncol 38: 1663-1673, 2011
APA
Sarkissyan, M., Mishra, D.K., Wu, Y., Shang, X., Sarkissyan, S., & Vadgama, J.V. (2011). IGF gene polymorphisms and breast cancer in African-American and Hispanic women. International Journal of Oncology, 38, 1663-1673. https://doi.org/10.3892/ijo.2011.990
MLA
Sarkissyan, M., Mishra, D. K., Wu, Y., Shang, X., Sarkissyan, S., Vadgama, J. V."IGF gene polymorphisms and breast cancer in African-American and Hispanic women". International Journal of Oncology 38.6 (2011): 1663-1673.
Chicago
Sarkissyan, M., Mishra, D. K., Wu, Y., Shang, X., Sarkissyan, S., Vadgama, J. V."IGF gene polymorphisms and breast cancer in African-American and Hispanic women". International Journal of Oncology 38, no. 6 (2011): 1663-1673. https://doi.org/10.3892/ijo.2011.990