Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity

  • Authors:
    • Philippe Fournier
    • Annette Arnold
    • Holger Wilden
    • Volker Schirrmacher
  • View Affiliations

  • Published online on: November 16, 2011     https://doi.org/10.3892/ijo.2011.1265
  • Pages: 840-850
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Abstract

Newcastle disease virus (NDV) is a negative sense RNA paramyxovirus of birds which in human tumor cells, in contrast to human non-tumor cells, has shown replication competence leading to tumor cell death (i.e., tumor selectivity and viral oncolysis). Our study demonstrates that this virus induces high levels of pro-inflammatory cytokines in the bronchial lavage fluid of mice after nasal application and also in vitro in human dendritic cells (DCs). NDV is known as a very efficient inductor of type I interferon (IFN). The presented data show the key role played by the cell surface receptor to type I IFN (IFNAR) but not by the interferon transcription factors IRF-3 and IRF-7 in the induction of the important pro-inflammatory cytokine IL-12 upon transcription of NDV genes in DCs. We show that NDV activates in infected cells the helicase RIG-I. In Tregs, the activation of RIG-I was shown in other studies to inhibit the suppressive function of these cells. We thus conclude that NDV in tumor therapy may help to stimulate T effector cells but also to block Treg cells, thereby alleviating a brake to antitumor activity.

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March 2012
Volume 40 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Fournier P, Arnold A, Wilden H and Schirrmacher V: Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity. Int J Oncol 40: 840-850, 2012
APA
Fournier, P., Arnold, A., Wilden, H., & Schirrmacher, V. (2012). Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity. International Journal of Oncology, 40, 840-850. https://doi.org/10.3892/ijo.2011.1265
MLA
Fournier, P., Arnold, A., Wilden, H., Schirrmacher, V."Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity". International Journal of Oncology 40.3 (2012): 840-850.
Chicago
Fournier, P., Arnold, A., Wilden, H., Schirrmacher, V."Newcastle disease virus induces pro-inflammatory conditions and type I interferon for counter-acting Treg activity". International Journal of Oncology 40, no. 3 (2012): 840-850. https://doi.org/10.3892/ijo.2011.1265