Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties

  • Authors:
    • Guopei Luo
    • Jiang Long
    • Xiaobo Cui
    • Zhiwen Xiao
    • Zuqiang Liu
    • Si Shi
    • Liang Liu
    • Chen Liu
    • Jin Xu
    • Min Li
    • Xianjun Yu
  • View Affiliations

  • Published online on: January 18, 2013     https://doi.org/10.3892/ijo.2013.1780
  • Pages: 979-984
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Abstract

Cancer stem cells are thought to be the origin of tumor metastasis. However, evidence of cancer stem cells as the source of lymphatic metastasis in pancreatic cancer is not clear. In this study, we examined the stem cell-like properties of the highly lymphatic metastatic pancreatic cancer cells BxPC-3-LN. Compared with the parental BxPC-3 cells, the BxPC-3-LN cells showed stem cell-like properties, including high lymphatic metastasis potential, self-renewal ability and chemoresistance. In addition, the BxPC-3-LN cells also expressed higher levels of sonic hedgehog and migrating cancer stem cell surface markers (CD133 and CXCR4) compared to the parental BxPC-3 cells. The growth of BxPC-3-LN cells was significantly inhibited by gemcitabine combined with the sonic hedgehog inhibitor cyclopamine. The BxPC-3-LN cells expressed lower levels of let-7, miR-34, miR-107, miR-125, miR-128, miR-130, miR-132 and miR-141 than the parental BxPC-3 cells detected by microRNA PCR array, which were reported to have close relation to stem cell factors. This study provides evidence that cancer stem cells are the major sources of pancreatic cancer lymphatic metastasis, and microRNAs may regulate lymphatic metastasis in pancreatic cancer through modulating cancer stem cells.
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March 2013
Volume 42 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Luo G, Long J, Cui X, Xiao Z, Liu Z, Shi S, Liu L, Liu C, Xu J, Li M, Li M, et al: Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties. Int J Oncol 42: 979-984, 2013
APA
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S. ... Yu, X. (2013). Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties. International Journal of Oncology, 42, 979-984. https://doi.org/10.3892/ijo.2013.1780
MLA
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S., Liu, L., Liu, C., Xu, J., Li, M., Yu, X."Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties". International Journal of Oncology 42.3 (2013): 979-984.
Chicago
Luo, G., Long, J., Cui, X., Xiao, Z., Liu, Z., Shi, S., Liu, L., Liu, C., Xu, J., Li, M., Yu, X."Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties". International Journal of Oncology 42, no. 3 (2013): 979-984. https://doi.org/10.3892/ijo.2013.1780