Roles of F‑box proteins in human digestive system tumors (Review)

  • Authors:
    • Jian Gong
    • Liang Lv
    • Jirong Huo
  • View Affiliations

  • Published online on: September 29, 2014     https://doi.org/10.3892/ijo.2014.2684
  • Pages: 2199-2207
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Abstract

F‑box proteins (FBPs), the substrate‑recognition subunit of E3 ubiquitin (Ub) ligase, are the important components of Ub proteasome system (UPS). FBPs are involved in multiple cellular processes through ubiquitylation and subsequent degradation of their target proteins. Many studies have described the roles of FBPs in human cancers. Digestive system tumors account for a large proportion of all the tumors, and their mortality is very high. This review summarizes for the first time the roles of FBPs in digestive system tumorige­nesis and tumor progression, aiming at finding new routes for the rational design of targeted anticancer therapies in digestive system tumors.
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December-2014
Volume 45 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Gong J, Lv L and Huo J: Roles of F‑box proteins in human digestive system tumors (Review). Int J Oncol 45: 2199-2207, 2014
APA
Gong, J., Lv, L., & Huo, J. (2014). Roles of F‑box proteins in human digestive system tumors (Review). International Journal of Oncology, 45, 2199-2207. https://doi.org/10.3892/ijo.2014.2684
MLA
Gong, J., Lv, L., Huo, J."Roles of F‑box proteins in human digestive system tumors (Review)". International Journal of Oncology 45.6 (2014): 2199-2207.
Chicago
Gong, J., Lv, L., Huo, J."Roles of F‑box proteins in human digestive system tumors (Review)". International Journal of Oncology 45, no. 6 (2014): 2199-2207. https://doi.org/10.3892/ijo.2014.2684