Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis

  • Authors:
    • Yoshinori Minami
    • Takaaki Sasaki
    • Hiroki Bochimoto
    • Jun‑Ichi Kawabe
    • Satoshi Endo
    • Yoshiki Hira
    • Tsuyoshi Watanabe
    • Shunsuke Okumura
    • Naoyuki Hasebe
    • Yoshinobu Ohsaki
  • View Affiliations

  • Published online on: November 28, 2014     https://doi.org/10.3892/ijo.2014.2783
  • Pages: 548-554
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Abstract

Prostaglandin I2 (PGI2) agonist has been reported to reduce tumor metastasis by modifying tumor angiogenesis; however, the mechanisms of how PGI2 affects the endothelial cells or pericytes in tumor vessel maturation are still unclear. The purpose of this study was to clarify the effects of PGI2 on tumor metastasis in a mouse lung metastasis model using Lewis lung carcinoma (LLC) cells. The mice were treated continuously with beraprost sodium (BPS), a PGI2 analog, for 3 weeks and then examined for lung metastases. The number and size of lung metastases were decreased significantly by BPS treatment. In addition, scanning electron microscopy and immunohistochemistry revealed that BPS increased the number of tumor‑associated pericytes and improved intratumor hypoxia. Collectively, this study suggests that BPS attenuated vascular functional maturation in metastatic tumors.
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February-2015
Volume 46 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Minami Y, Sasaki T, Bochimoto H, Kawabe JI, Endo S, Hira Y, Watanabe T, Okumura S, Hasebe N, Ohsaki Y, Ohsaki Y, et al: Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis. Int J Oncol 46: 548-554, 2015
APA
Minami, Y., Sasaki, T., Bochimoto, H., Kawabe, J., Endo, S., Hira, Y. ... Ohsaki, Y. (2015). Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis. International Journal of Oncology, 46, 548-554. https://doi.org/10.3892/ijo.2014.2783
MLA
Minami, Y., Sasaki, T., Bochimoto, H., Kawabe, J., Endo, S., Hira, Y., Watanabe, T., Okumura, S., Hasebe, N., Ohsaki, Y."Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis". International Journal of Oncology 46.2 (2015): 548-554.
Chicago
Minami, Y., Sasaki, T., Bochimoto, H., Kawabe, J., Endo, S., Hira, Y., Watanabe, T., Okumura, S., Hasebe, N., Ohsaki, Y."Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis". International Journal of Oncology 46, no. 2 (2015): 548-554. https://doi.org/10.3892/ijo.2014.2783