RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9

  • Authors:
    • Zhikui Liu
    • Changwei Dou
    • Yuli Jia
    • Qing Li
    • Xin Zheng
    • Yingmin Yao
    • Qingguang Liu
    • Tao Song
  • View Affiliations

  • Published online on: January 26, 2015     https://doi.org/10.3892/ijo.2015.2853
  • Pages: 1710-1720
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Abstract

The retinoic acid-induced protein I (Rig-I/Ddx58), (RIG-I) initiates a signaling cascade that induces innate immune defences which is associated with the production of type I interferons (IFNs) and inflammatory cytokines to establish an antiviral state. Aberrant RIG-I signaling leads to inflammation, autoimmune diseases and cancer. However, the role of RIG-I in hepatocellular carcinoma (HCC) is still unknown. Here, we observed that RIG-I expression was downregulated in HCC tissues and loss of RIG-I expression was correlated with poor clinicopathological features. Additionally, we demonstrated that patients with positive RIG-I expression had a better 3-year survival and RIG-I was an independent factor for predicting the prognosis of HCC patients. Elevated RIG-I expression inhibited the proliferation, migration, and invasion of HCC. Inhibiting RIG-I with its specific siRNA was able to attenuate the malignant behavior of HCC cells. Moreover, RIG-I inhibited the invasive behavior through downregulating matrix metalloproteinase-9 (MMP9). Mechanistically, RIG-I enhances IFN-α response by amplifying IFN-α effecter signaling via strengthening STAT1 activation. Addressing this pathway, we identified that RIG-I may serve as a prognostic marker and that MMP9 may be a potential target of RIG-I in HCC.
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April-2015
Volume 46 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Liu Z, Dou C, Jia Y, Li Q, Zheng X, Yao Y, Liu Q and Song T: RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9. Int J Oncol 46: 1710-1720, 2015
APA
Liu, Z., Dou, C., Jia, Y., Li, Q., Zheng, X., Yao, Y. ... Song, T. (2015). RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9. International Journal of Oncology, 46, 1710-1720. https://doi.org/10.3892/ijo.2015.2853
MLA
Liu, Z., Dou, C., Jia, Y., Li, Q., Zheng, X., Yao, Y., Liu, Q., Song, T."RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9". International Journal of Oncology 46.4 (2015): 1710-1720.
Chicago
Liu, Z., Dou, C., Jia, Y., Li, Q., Zheng, X., Yao, Y., Liu, Q., Song, T."RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9". International Journal of Oncology 46, no. 4 (2015): 1710-1720. https://doi.org/10.3892/ijo.2015.2853