Molecular aspects of breast cancer resistance to drugs (Review)

  • Authors:
    • Gloria M. Calaf
    • Andrea B. Zepeda
    • Rodrigo L. Castillo
    • Carolina A. Figueroa
    • Consuelo Arias
    • Elías Figueroa
    • Jorge G. Farías
  • View Affiliations

  • Published online on: June 18, 2015     https://doi.org/10.3892/ijo.2015.3055
  • Pages: 437-445
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of neoplasia remains a leading cause of cancer-related death in women worldwide. Carcinogenesis takes a progressive course from somatic mutations, alteration of the DNA repair mechanisms, inhibition of growth suppressors, followed by cell proliferation, tissue invasion and risk of metastasis. Less than 10% of all cancers are hereditary, and in the case of breast cancer only 8%, a phenomenon linked to genetic changes in BRCA1 or BRCA2. All the other cancers can be caused by an infection (15%) or in most cases (75%) the etiology is unknown. Patients with genetic mutations in BRCA1 or BRCA2 have 30-60% likelihood of developing a second primary breast cancer and between 11 and 45% risk of ovarian cancer, HER-2/neu is overexpressed in ~30% of human breast tumors and it has a predictive role in chemotherapy and endocrine therapy.
View Figures
View References

Related Articles

Journal Cover

August-2015
Volume 47 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Calaf GM, Zepeda AB, Castillo RL, Figueroa CA, Arias C, Figueroa E and Farías JG: Molecular aspects of breast cancer resistance to drugs (Review). Int J Oncol 47: 437-445, 2015
APA
Calaf, G.M., Zepeda, A.B., Castillo, R.L., Figueroa, C.A., Arias, C., Figueroa, E., & Farías, J.G. (2015). Molecular aspects of breast cancer resistance to drugs (Review). International Journal of Oncology, 47, 437-445. https://doi.org/10.3892/ijo.2015.3055
MLA
Calaf, G. M., Zepeda, A. B., Castillo, R. L., Figueroa, C. A., Arias, C., Figueroa, E., Farías, J. G."Molecular aspects of breast cancer resistance to drugs (Review)". International Journal of Oncology 47.2 (2015): 437-445.
Chicago
Calaf, G. M., Zepeda, A. B., Castillo, R. L., Figueroa, C. A., Arias, C., Figueroa, E., Farías, J. G."Molecular aspects of breast cancer resistance to drugs (Review)". International Journal of Oncology 47, no. 2 (2015): 437-445. https://doi.org/10.3892/ijo.2015.3055