RELEASE OF EPIDERMAL GROWTH-FACTOR TRANSFORMING GROWTH-FACTOR-ALPHA BY OVARIAN-TUMORS IN-VITRO
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- Published online on: October 1, 1994 https://doi.org/10.3892/ijo.5.4.781
- Pages: 781-786
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Abstract
EGF-like activity was measured in media from 3-hour incubations of ovarian tissue from 27 patients with normal postmenopausal ovaries, malignant or benign epithelial tumours. EGF-like activity in the medium was measured using a radioreceptor assay. Malignant tumour tissue released significantly more EGF/TGF-alpha than benign tissues and aneuploid carcinomas more than diploid carcinomas. In spite of varying amounts of tumour cells there was a strong correlation in EGF/TCF-alpha release from the different tissue samples of each patient suggesting paracrine rather than autocrine regulation. The level of EGF-like activity may be a feature of the patient rather than of the tumour cells.