Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression

  • Authors:
    • Kenji Niwa
    • Kokyo Onogi
    • Yun Wu
    • Hideki Mori
    • Yosuke Inoue
    • Teruhiko Tamaya
  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/mmr.1.1.119
  • Pages: 119-122
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Abstract

This study was performed to identify the contribution of cimetidine to chemotherapy for epithelial ovarian carcinoma. Cimetidine was administered two weeks before surgery in combination with platinum-based chemotherapy, and the treatment was continued for two years. Cyclooxygenase-2 (COX-2) expression was also evaluated. The chemotherapy regimens did not affect patient prognosis. The effect of cimetidine was more marked in patients who showed overexpression of COX-2. Platinum-based chemotherapy combined with cimetidine, as a first-line therapy, may improve the prognosis of patients with advanced serous ovarian carcinoma.

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January-February 2008
Volume 1 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Niwa K, Onogi K, Wu Y, Mori H, Inoue Y and Tamaya T: Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression. Mol Med Rep 1: 119-122, 2008
APA
Niwa, K., Onogi, K., Wu, Y., Mori, H., Inoue, Y., & Tamaya, T. (2008). Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression. Molecular Medicine Reports, 1, 119-122. https://doi.org/10.3892/mmr.1.1.119
MLA
Niwa, K., Onogi, K., Wu, Y., Mori, H., Inoue, Y., Tamaya, T."Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression". Molecular Medicine Reports 1.1 (2008): 119-122.
Chicago
Niwa, K., Onogi, K., Wu, Y., Mori, H., Inoue, Y., Tamaya, T."Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression". Molecular Medicine Reports 1, no. 1 (2008): 119-122. https://doi.org/10.3892/mmr.1.1.119