Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic‑ischemic brain injury by up‑regulating brain‑derived neurotrophic factor

  • Authors:
    • Jin Sun
    • Yunxia Qu
    • Huiming He
    • Xiaolei Fan
    • Yuanhua Qin
    • Weifeng Mao
    • Lixin Xu
  • View Affiliations

  • Published online on: September 18, 2014     https://doi.org/10.3892/mmr.2014.2577
  • Pages: 3047-3051
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Abstract

Polydatin is a key component of Polygonum cuspidatum, a herb with medical and nutritional value. The present study investigated the protective effect of polydatin against learning and memory impairment in neonatal rats with hypoxic‑ischemic brain injury (HIBI). The unilateral common carotid artery ligation method was used to generate neonatal HIBI rats. Y‑maze testing revealed that rats with HIBI exhibited memory impairment, while rats with HIBI treated with polydatin displayed enhanced long‑term learning and memory. Of note, polydatin was found to upregulate the expression of hippocampal brain‑derived neurotrophic factor (BDNF) in rats with HIBI. BDNF has a role in protecting HIBI‑induced brain tissue injury and alleviating memory impairment. These findings showed that polydatin had a protective effect against learning and memory impairment in neonatal rats with HIBI and that the protective effect may be mediated through the upregulation of BDNF.
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December-2014
Volume 10 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Sun J, Qu Y, He H, Fan X, Qin Y, Mao W and Xu L: Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic‑ischemic brain injury by up‑regulating brain‑derived neurotrophic factor. Mol Med Rep 10: 3047-3051, 2014
APA
Sun, J., Qu, Y., He, H., Fan, X., Qin, Y., Mao, W., & Xu, L. (2014). Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic‑ischemic brain injury by up‑regulating brain‑derived neurotrophic factor. Molecular Medicine Reports, 10, 3047-3051. https://doi.org/10.3892/mmr.2014.2577
MLA
Sun, J., Qu, Y., He, H., Fan, X., Qin, Y., Mao, W., Xu, L."Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic‑ischemic brain injury by up‑regulating brain‑derived neurotrophic factor". Molecular Medicine Reports 10.6 (2014): 3047-3051.
Chicago
Sun, J., Qu, Y., He, H., Fan, X., Qin, Y., Mao, W., Xu, L."Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic‑ischemic brain injury by up‑regulating brain‑derived neurotrophic factor". Molecular Medicine Reports 10, no. 6 (2014): 3047-3051. https://doi.org/10.3892/mmr.2014.2577