Increased immunoreactivity of c‑Fos in the spinal cord of the aged mouse and dog

  • Authors:
    • Ji Hyeon Ahn
    • Myoung Chul Shin
    • Joon Ha Park
    • In Hye Kim
    • Jae‑Chul Lee
    • Bing Chun Yan
    • In Koo Hwang
    • Seung Myung Moon
    • Ji Yun Ahn
    • Taek Geun Ohk
    • Tae Hun Lee
    • Jun Hwi Cho
    • Hyung‑Cheul Shin
    • Moo‑Ho Won
  • View Affiliations

  • Published online on: October 29, 2014     https://doi.org/10.3892/mmr.2014.2800
  • Pages: 1043-1048
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Abstract

Expression of c‑Fos in the spinal cord following nociceptive stimulation is considered to be a neurotoxic biomarker. In the present study, the immunoreactivity of c‑Fos in the spinal cord was compared between young adult (2‑3 years in dogs and 6 months in mice) and aged (10‑12 years in dogs and 24 months in mice) Beagle dogs and C57BL/6J mice. In addition, changes to neuronal distribution and damage to the spinal cord were also investigated. There were no significant differences in neuronal loss or degeneration of the spinal neurons observed in either the aged dogs or mice. Weak c‑Fos immunoreactivity was observed in the spinal neurons of the young adult animals; however, c‑Fos immunoreactivity was markedly increased in the nuclei of spinal neurons in the aged dogs and mice, as compared with that of the young adults. In conclusion, c‑Fos immunoreactivity was significantly increased without any accompanying neuronal loss in the aged spinal cord of mice and dogs, as compared with the spinal cords of the young adult animals.
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February-2015
Volume 11 Issue 2

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Online ISSN:1791-3004

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Spandidos Publications style
Ahn JH, Shin MC, Park JH, Kim IH, Lee JC, Yan BC, Hwang IK, Moon SM, Ahn JY, Ohk TG, Ohk TG, et al: Increased immunoreactivity of c‑Fos in the spinal cord of the aged mouse and dog. Mol Med Rep 11: 1043-1048, 2015
APA
Ahn, J.H., Shin, M.C., Park, J.H., Kim, I.H., Lee, J., Yan, B.C. ... Won, M. (2015). Increased immunoreactivity of c‑Fos in the spinal cord of the aged mouse and dog. Molecular Medicine Reports, 11, 1043-1048. https://doi.org/10.3892/mmr.2014.2800
MLA
Ahn, J. H., Shin, M. C., Park, J. H., Kim, I. H., Lee, J., Yan, B. C., Hwang, I. K., Moon, S. M., Ahn, J. Y., Ohk, T. G., Lee, T. H., Cho, J. H., Shin, H., Won, M."Increased immunoreactivity of c‑Fos in the spinal cord of the aged mouse and dog". Molecular Medicine Reports 11.2 (2015): 1043-1048.
Chicago
Ahn, J. H., Shin, M. C., Park, J. H., Kim, I. H., Lee, J., Yan, B. C., Hwang, I. K., Moon, S. M., Ahn, J. Y., Ohk, T. G., Lee, T. H., Cho, J. H., Shin, H., Won, M."Increased immunoreactivity of c‑Fos in the spinal cord of the aged mouse and dog". Molecular Medicine Reports 11, no. 2 (2015): 1043-1048. https://doi.org/10.3892/mmr.2014.2800