Identification of miR‑125a‑5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis

  • Authors:
    • Duqun Chen
    • Yifan Li
    • Zhengming Su
    • Zuhu Yu
    • Wenshui Yu
    • Yuchi Li
    • Yaoting Gui
    • Shangqi Yang
    • Yongqing Lai
  • View Affiliations

  • Published online on: November 3, 2014     https://doi.org/10.3892/mmr.2014.2848
  • Pages: 1278-1283
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

miR‑125a‑5p has been previously described as a tumor suppressor in numerous malignancies, however the expression and function of miR‑125a‑5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, to explore the potential role of miR‑125a‑5p in RCC, quantitative polymerase chain reaction was used to determine the expression levels of miR‑125a‑5p in renal cancer tissues. The influence of miR‑125a‑5p on cell proliferation, migration and apoptosis was also determined, using an MTT assay, a wound scratch assay and flow cytometry, respectively. The expression of miR‑125a‑5p was shown to be decreased in RCC and the restoration of miR‑125a‑5p by synthetic mimics was shown to suppress cell proliferation and migration, and induce apoptosis. The present results indicate that miR‑125a‑5p may function as a tumor suppressor in RCC. The present study is, to the best of our knowledge, the first to demonstrate the downregulation of miR‑125a‑5p in RCC, and to show the role it has in affecting cellular proliferation, migration and apoptosis. Further research is needed to define the target genes of miR‑125a‑5p and explore the potential of miR‑125a‑5p as a diagnostic or a prognostic biomarker for RCC.
View Figures
View References

Related Articles

Journal Cover

February-2015
Volume 11 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen D, Li Y, Su Z, Yu Z, Yu W, Li Y, Gui Y, Yang S and Lai Y: Identification of miR‑125a‑5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis. Mol Med Rep 11: 1278-1283, 2015
APA
Chen, D., Li, Y., Su, Z., Yu, Z., Yu, W., Li, Y. ... Lai, Y. (2015). Identification of miR‑125a‑5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis. Molecular Medicine Reports, 11, 1278-1283. https://doi.org/10.3892/mmr.2014.2848
MLA
Chen, D., Li, Y., Su, Z., Yu, Z., Yu, W., Li, Y., Gui, Y., Yang, S., Lai, Y."Identification of miR‑125a‑5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis". Molecular Medicine Reports 11.2 (2015): 1278-1283.
Chicago
Chen, D., Li, Y., Su, Z., Yu, Z., Yu, W., Li, Y., Gui, Y., Yang, S., Lai, Y."Identification of miR‑125a‑5p as a tumor suppressor of renal cell carcinoma, regulating cellular proliferation, migration and apoptosis". Molecular Medicine Reports 11, no. 2 (2015): 1278-1283. https://doi.org/10.3892/mmr.2014.2848