Open Access

Hepatitis C virus represses the cellular antiviral response by upregulating the expression of signal transducer and activator of transcription 3 through sponging microRNA‑122

  • Authors:
    • Yulin Xiong
    • Changjiang Zhang
    • Jing Yuan
    • Yan Zhu
    • Zhaoxia  Tan
    • Xuemei Kuang
    • Xiaohong Wang
  • View Affiliations

  • Published online on: November 7, 2014     https://doi.org/10.3892/mmr.2014.2897
  • Pages: 1733-1737
  • Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

microRNAs (miRNAs) are small, non‑coding RNAs that inhibit the expression of target protein coding genes at the post‑transcriptional level. miR‑122 is a liver specific miRNA. Notably, miR‑122 is used by the hepatitis C virus (HCV) for triggering viral replication by interacting with the 5' untranslated region of the HCV RNA. The present study demonstrated that miR‑122 inhibited the expression of signal transducer and activator of transcription 3 (STAT3), an antivirus response repressor. The HCV RNA acted as an ʻmiRNA spongeʼ, which upregulated the expression of STAT3 by sealing miR‑122. Subsequently, it was confirmed that this miR‑122 sponge function of HCV RNA repressed the expression of polyinosinic‑polycytidylic acid‑stimulated type I interferons. The present study provided a deeper understanding of the complex role of miR‑122 in the progression of HCV infection and supported the miR‑122 inhibition strategy in anti‑HCV infection treatment.
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March-2015
Volume 11 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Xiong Y, Zhang C, Yuan J, Zhu Y, Tan Z, Kuang X and Wang X: Hepatitis C virus represses the cellular antiviral response by upregulating the expression of signal transducer and activator of transcription 3 through sponging microRNA‑122. Mol Med Rep 11: 1733-1737, 2015
APA
Xiong, Y., Zhang, C., Yuan, J., Zhu, Y., Tan, Z., Kuang, X., & Wang, X. (2015). Hepatitis C virus represses the cellular antiviral response by upregulating the expression of signal transducer and activator of transcription 3 through sponging microRNA‑122. Molecular Medicine Reports, 11, 1733-1737. https://doi.org/10.3892/mmr.2014.2897
MLA
Xiong, Y., Zhang, C., Yuan, J., Zhu, Y., Tan, Z., Kuang, X., Wang, X."Hepatitis C virus represses the cellular antiviral response by upregulating the expression of signal transducer and activator of transcription 3 through sponging microRNA‑122". Molecular Medicine Reports 11.3 (2015): 1733-1737.
Chicago
Xiong, Y., Zhang, C., Yuan, J., Zhu, Y., Tan, Z., Kuang, X., Wang, X."Hepatitis C virus represses the cellular antiviral response by upregulating the expression of signal transducer and activator of transcription 3 through sponging microRNA‑122". Molecular Medicine Reports 11, no. 3 (2015): 1733-1737. https://doi.org/10.3892/mmr.2014.2897