Suppression of dendritic cell and T-cell activation by the pRST98 Salmonella plasmid

  • Authors:
    • Li Wei
    • Qili Jin
    • Yuanyuan Chu
    • Shuyan Wu
    • Rui Huang
  • View Affiliations

  • Published online on: November 10, 2014     https://doi.org/10.3892/mmr.2014.2919
  • Pages: 2306-2314
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Abstract

Salmonella evades host immune response via the expression of a variety of pathogenic factors. The ‘pRST98’ plasmid of Salmonella enterica serotype Typhi (S. Typhi) is involved in conferring the multidrug‑resistance and virulence of S. typhi. However, its specific effect on host‑cell function has remained elusive. Dendritic cells (DCs) are key regulators of immune responses. The present study therefore aimed to investigate whether pRST98 may target DCs involved in mediating the adaptive immune response. In vivo experiments with Salmonella enterica serotype Typhimurium χ3337 and χ3337/pRST98 revealed that pRST98 may influence multiple important functions of murine DCs, including maturation, survival and cytokine production. In addition, pRST98 markedly contributed to decreasing T‑cell activation. These data suggested that by targeting the aforementioned functions of DCs, pRST98 may partially overturn the adaptive immune defense mechanisms of the host, which are required for elimination of this pathogen from infected tissues. This may contribute to the evasion of host adaptive immune responses by S. Typhi and therefore provide a target for the prevention and treatment of typhoid fever.
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March-2015
Volume 11 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wei L, Jin Q, Chu Y, Wu S and Huang R: Suppression of dendritic cell and T-cell activation by the pRST98 Salmonella plasmid. Mol Med Rep 11: 2306-2314, 2015
APA
Wei, L., Jin, Q., Chu, Y., Wu, S., & Huang, R. (2015). Suppression of dendritic cell and T-cell activation by the pRST98 Salmonella plasmid. Molecular Medicine Reports, 11, 2306-2314. https://doi.org/10.3892/mmr.2014.2919
MLA
Wei, L., Jin, Q., Chu, Y., Wu, S., Huang, R."Suppression of dendritic cell and T-cell activation by the pRST98 Salmonella plasmid". Molecular Medicine Reports 11.3 (2015): 2306-2314.
Chicago
Wei, L., Jin, Q., Chu, Y., Wu, S., Huang, R."Suppression of dendritic cell and T-cell activation by the pRST98 Salmonella plasmid". Molecular Medicine Reports 11, no. 3 (2015): 2306-2314. https://doi.org/10.3892/mmr.2014.2919