Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling

  • Authors:
    • Ying Li
    • Xiaohua Huang
    • Congcong Wang
    • Yuzhong Li
    • Mingchun Luan
    • Keli Ma
  • View Affiliations

  • Published online on: December 12, 2014     https://doi.org/10.3892/mmr.2014.3087
  • Pages: 2959-2966
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Abstract

The ganglioside GM3 exerts its different effects via various growth factor receptors. The present study investigated and comparatively analyzed the opposing effects exerted by GM3 on the migration of mouse hepatocellular carcinoma Hepa1‑6 cells via epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (HGFR/cMet). The results demonstrated that GM3 inhibited EGF‑stimulated motility, but promoted HGF‑stimulated motility of the Hepa1‑6 cells via phosphatidylinositol 3‑kinase/Akt‑mediated migration signaling. It is well established that the main cytokines modulating cell proliferation, invasion and metastasis are different in different types of tumor. This difference may, at least in part, explain why GM3 exerted its actions in a tumor‑type specific manner.
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April-2015
Volume 11 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li Y, Huang X, Wang C, Li Y, Luan M and Ma K: Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling. Mol Med Rep 11: 2959-2966, 2015
APA
Li, Y., Huang, X., Wang, C., Li, Y., Luan, M., & Ma, K. (2015). Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling. Molecular Medicine Reports, 11, 2959-2966. https://doi.org/10.3892/mmr.2014.3087
MLA
Li, Y., Huang, X., Wang, C., Li, Y., Luan, M., Ma, K."Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling". Molecular Medicine Reports 11.4 (2015): 2959-2966.
Chicago
Li, Y., Huang, X., Wang, C., Li, Y., Luan, M., Ma, K."Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling". Molecular Medicine Reports 11, no. 4 (2015): 2959-2966. https://doi.org/10.3892/mmr.2014.3087