MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression

Zhou,Wen‑Yu; Chen,Jin‑Chan; Jiao,Ting‑Ting; Hui,Ning; Qi,Xuan

doi:10.3892/mmr.2015.3324

MicroRNA-181 targets Yin Yang 1 expression and inhibits cervical cancer progression

Authors:
- Wen‑Yu Zhou
- Jin‑Chan Chen
- Ting‑Ting Jiao
- Ning Hui
- Xuan Qi
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Affiliations: Department of Obstetrics and Gynecology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China, Department of Obstetrics and Gynecology, Shanghai Chinese Armed Police Forces Hospital, Shanghai 200051, P.R. China
Published online on: February 10, 2015 https://doi.org/10.3892/mmr.2015.3324
Pages: 4541-4546

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Abstract

Dysregulated expression of microRNAs (miRNAs) has been observed in numerous types of human cancer, including cervical cancer (CC). The present study aimed to elucidate the expression and roles of miR‑181 in cervical cancer tissues and cells. HeLa cells with a stable overexpression of miR‑181 were generated and injected subcutaneously into the front legs of nude mice. Functional assays revealed a reduced rate of proliferation and an enhanced rate of apoptosis following transfection of CC cells with miR‑181 mimics. In addition, miR‑181 also suppressed tumor growth in the nude mice. At the molecular level, it was found that Yin Yang 1, an oncogene in several types of human cancer, was negatively regulated by miR‑181. Therefore, the findings of the present study suggest that exogenous overexpression of miR‑181 may be a potential approach for the treatment of CC in the future.

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