Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus

  • Authors:
    • Dae‑Ki Joung
    • Sung‑Hoon Choi
    • Ok‑Hwa Kang
    • Sung‑Bae Kim
    • Su‑Hyun Mun
    • Yun‑Soo Seo
    • Da-Hye Kang
    • Ryong Gong
    • Dong‑Won Shin
    • Youn-Chul Kim
    • Dong‑Yeul Kwon
  • View Affiliations

  • Published online on: February 12, 2015     https://doi.org/10.3892/mmr.2015.3345
  • Pages: 663-667
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Abstract

Methicillin‑resistant Staphylococcus aureus (MRSA) infection is a serious clinical problem worldwide. The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin‑susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay, MTT colorimetric assay, checkerboard dilution test and time‑kill assay. The MIC of ORV for all strains was moderate at 125 µg/ml. Of note, the antimicrobial activity and fractional inhibitory concentration index values of ORV were markedly increased in the presence of a non‑growth inhibitory dose of certain antibiotics. Time‑kill curves revealed that a combination of ORV with ciprofloxacin or with gentamicin reduced bacterial counts to below the lowest detectable limit after 24 h. These effective combinations may be used as potential antimicrobial regimens for use in the management of MRSA.
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July-2015
Volume 12 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Joung DK, Choi SH, Kang OH, Kim SB, Mun SH, Seo YS, Kang D, Gong R, Shin DW, Kim Y, Kim Y, et al: Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus. Mol Med Rep 12: 663-667, 2015
APA
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y. ... Kwon, D. (2015). Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus. Molecular Medicine Reports, 12, 663-667. https://doi.org/10.3892/mmr.2015.3345
MLA
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y., Kang, D., Gong, R., Shin, D., Kim, Y., Kwon, D."Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus". Molecular Medicine Reports 12.1 (2015): 663-667.
Chicago
Joung, D., Choi, S., Kang, O., Kim, S., Mun, S., Seo, Y., Kang, D., Gong, R., Shin, D., Kim, Y., Kwon, D."Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus". Molecular Medicine Reports 12, no. 1 (2015): 663-667. https://doi.org/10.3892/mmr.2015.3345