DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells

  • Authors:
    • Xiao‑Lin Zhu
    • Wei Sun
    • Wen‑Bin Lei
    • Hui‑Wen Zhuang
    • Wei‑Jian Hou
    • Wei‑Ping Wen
  • View Affiliations

  • Published online on: April 15, 2015     https://doi.org/10.3892/mmr.2015.3617
  • Pages: 2003-2008
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Abstract

DJ-1, a novel mitogen-dependent oncogene, has an important role in the progression of human malignancies, whereas tumor suppressor phosphatase and tensin homolog (PTEN) is known to control a variety of processes associated with cell survival, proliferation and invasion. DJ‑1 overexpression was reported to be negatively correlated with PTEN expression in tumor tissues of patients with laryngeal squamous cell carcinoma (LSCC). In the present study, the effect of DJ‑1 on PTEN in laryngeal cancer cells was investigated by transfecting DJ‑1‑specific small interfering (si)RNA into Hep‑2 and SNU‑899 cells. Cell survival and cell proliferative and invasive capacity were then evaluated. The results showed that siRNA targeting of DJ‑1 effectively upregulated PTEN expression, resulting in enhanced cell death as well as decreased proliferation and invasion of Hep‑2 and SNU‑899 cells. The results of the present study indicated, for the first time, to the best of our knowledge, that DJ‑1‑induced PTEN downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. The DJ-1 gene may have an important role in the tumorigenesis of LSCC.
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August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhu XL, Sun W, Lei WB, Zhuang HW, Hou WJ and Wen WP: DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. Mol Med Rep 12: 2003-2008, 2015
APA
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., & Wen, W. (2015). DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. Molecular Medicine Reports, 12, 2003-2008. https://doi.org/10.3892/mmr.2015.3617
MLA
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., Wen, W."DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells". Molecular Medicine Reports 12.2 (2015): 2003-2008.
Chicago
Zhu, X., Sun, W., Lei, W., Zhuang, H., Hou, W., Wen, W."DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells". Molecular Medicine Reports 12, no. 2 (2015): 2003-2008. https://doi.org/10.3892/mmr.2015.3617