Inhibiting Notch‑1 reduces the expression of Toll‑like receptor 9 in BABL/C‑lpr mouse kidneys and improves glucocorticoid sensitivity

  • Authors:
    • Gong Xiao
    • Wangbin Ning
    • Chunhu Zhang
    • Shiyao Wu
    • Xiaoxia Zuo
  • View Affiliations

  • Published online on: May 8, 2015     https://doi.org/10.3892/mmr.2015.3758
  • Pages: 2765-2770
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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, characterized by the development of a pathogenic autoantibodies. Lupus nephritis is a major cause of mortality in patients with SLE. Glucocorticoids are used for the treatment of lupus, however, corticosteroids have no effect on the expression of Toll‑like receptor 9 (TLR9), which may limit response to corticosteroids in certain patients with SLR. The expression of TLR9 can be used as a predictor of glucocorticoid response in patients with active SLE. The present study analyzed urine proteins and pathological kidney sections of BABL/C‑lpr mice and found that, following the inhibition of Notch1, glucocorticoid treatment improved the symptoms of lupus nephritis. Furthermore, glucocorticoid treatment reduced the expression of TLR9 in the BABL/C‑lpr mouse kidneys, according to immunohistochemical and western blot analyses. These results suggested that inhibition of the expression of Notch‑1 enhanced corticosteroid sensitivity in BABL/C‑lpr mice.
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August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Xiao G, Ning W, Zhang C, Wu S and Zuo X: Inhibiting Notch‑1 reduces the expression of Toll‑like receptor 9 in BABL/C‑lpr mouse kidneys and improves glucocorticoid sensitivity. Mol Med Rep 12: 2765-2770, 2015
APA
Xiao, G., Ning, W., Zhang, C., Wu, S., & Zuo, X. (2015). Inhibiting Notch‑1 reduces the expression of Toll‑like receptor 9 in BABL/C‑lpr mouse kidneys and improves glucocorticoid sensitivity. Molecular Medicine Reports, 12, 2765-2770. https://doi.org/10.3892/mmr.2015.3758
MLA
Xiao, G., Ning, W., Zhang, C., Wu, S., Zuo, X."Inhibiting Notch‑1 reduces the expression of Toll‑like receptor 9 in BABL/C‑lpr mouse kidneys and improves glucocorticoid sensitivity". Molecular Medicine Reports 12.2 (2015): 2765-2770.
Chicago
Xiao, G., Ning, W., Zhang, C., Wu, S., Zuo, X."Inhibiting Notch‑1 reduces the expression of Toll‑like receptor 9 in BABL/C‑lpr mouse kidneys and improves glucocorticoid sensitivity". Molecular Medicine Reports 12, no. 2 (2015): 2765-2770. https://doi.org/10.3892/mmr.2015.3758